- A new strategy for the synthesis of β-benzylmercaptoethylamine derivatives
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Here, we describe a new experimental approach to the synthesis of the β-benzylmercaptoethylamine functionality, and illustrate its synthetic utility in multi-component reactions. Although prevalent in modern organic synthesis, no general methods have been described for this functionality. Using a carefully developed LiOH-water-ethanol reaction mixture, we were able to produce a diverse collection of β-benzylmercaptoethylamines containing a range of sensitive functional groups in excellent yields. To further illustrate their utility in molecular library synthesis, we also report the use of β-benzylmercaptoethylamines in five different multi-component reactions.
- Ghosh, Subrata,Tochtrop, Gregory P.
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supporting information; experimental part
p. 1723 - 1726
(2009/07/05)
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- Synthesis and histamine H2-agonistic activity of ring-substituted phenyl analogues of impromidine
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Analogues of the H2-agonist impromidine, characterized by a substituted phenyl ring instead of the 5-methyl-4-imidazolyl group, were prepared and tested for their H2-agonistic and H1-antagonistic activity at the guinea-pig
- Buschauer,Lachenmayr,Schunack
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p. 840 - 845
(2007/10/02)
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