- Synthesis and transformations of di-endo-3-aminobicyclo-[2.2.2]oct-5-ene-2- carboxylic acid derivatives
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all-endo-3-amino-5-hydroxybicyclo[2.2.2]octane-2-carboxylic acid (13) and allendo-5-amino-6-(hydroxymethyl)bicyclo[2.2.2]octan-2-ol (10) were prepared via dihydro-1,3-oxazine or γ-lactone intermediates by the stereoselective functionalization of an Nprotected derivative of endo-3-aminobicyclo[2.2.2]oct- 5-ene-2-carboxylic acid (2). Ring closure of β-amino ester 4 resulted in tricyclic pyrimidinones 15 and 16. The structures, stereochemistry and relative configurations of the synthesized compounds were determined by IR and NMR.
- Palko, Marta,Sohar, Pal,Fueloep, Ferenc
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- Continuous-flow retro-Diels-Alder reaction: An efficient method for the preparation of pyrimidinone derivatives
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The syntheses of various pyrimidinones as potentially bioactive products by means of the highly controlled continuous-flow retro-Diels-Alder reaction of condensed pyrimidinone derivatives are presented. Noteworthy, the use of this approach allowed us to r
- Nekkaa, Imane,Palkó, Márta,Mándity, István M.,Fül?p, Ferenc
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supporting information
p. 318 - 324
(2018/02/19)
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- 7-PHENOXYCHROMAN CARBOXYLIC ACID DERIVATIVES
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Compounds of Formula I: (I) in which A, A1, R1, R7a, R7b, R8 and R10 have the meanings given in the specification, are DP2 receptor inhibitors useful in the treatment of useful in the treat
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Page/Page column 119
(2010/07/09)
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- A Facile Method for the Preparation of 2-Substituted Pyrimidin-4(3H)-ones by a Retro-Diels-Alder Reaction
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diexo-3-Aza-4-oxotricyclo2.5>non-7-ene (1) reacted with carboximidic esters by ring expansion to yield tricyclic 5,6-dihydropyrimidin-4(3H)-ones 3; when the latter were refluxed in chlorobenzene solution, cyclopentadiene split off to gi
- Stajer, Geza,Szabo, Angela E.,Bernath, Gabor,Sohar, Pal
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p. 290 - 292
(2007/10/02)
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