Enantioselective synthesis of phenyl-ethanolamines through application of chiral sulfoxide
Efficient enantioselective synthesis of (R)- and (S)-enantiomers of 2-(tert-butylamino)-1-(p-methoxyphenyl)-ethanol has been achieved in high enantiomeric excess by using asymmetric sulfoxide as a chiral auxiliary. The present synthetic approach was further extended to the asymmetric synthesis of (R)-salbutamol. Copyright Taylor & Francis Group, LLC.
Sivakumar, Aathimanivelu V.,Lahoti, Anand M.,Bhat, Sujata V.
experimental part
p. 3338 - 3347
(2011/03/19)
A convenient synthesis of (R)-salmeterol via Rh-catalyzed asymmetric transfer hydrogenation
(R)-Salmeterol was synthesized in eight steps with salicaldehyde as the starting material. The key chiral intermediate, alcohol 5, was prepared via Rh-catalyzed asymmetric transfer hydrogenation with (S,S)-PEG-BsDPEN or (S,S)-TsDPEN ligand and sodium formate as the hydrogen donor under mild conditions.
Liu, Juntao,Zhou, Di,Jia, Xian,Huang, Ling,Li, Xingshu,Chan, Albert S.C.
p. 1824 - 1828
(2008/12/22)
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