106782-22-3

Basic information

• Product Name: Ethanol, 2-[(4-pyridinylmethylene)amino]- (9CI)
• Synonyms: Ethanol, 2-[(4-pyridinylmethylene)amino]- (9CI)
• CAS NO: 106782-22-3
• Molecular Formula: C₈H₁₀N₂O
• Molecular Weight: 150.1778
• Product Categories: PYRIDINE
• Mol File: 106782-22-3.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Ethanol, 2-[(4-pyridinylmethylene)amino]- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanol, 2-[(4-pyridinylmethylene)amino]- (9CI)(106782-22-3)
• EPA Substance Registry System: Ethanol, 2-[(4-pyridinylmethylene)amino]- (9CI)(106782-22-3)

Safety Data

• Hazardous Substances Data: 106782-22-3(Hazardous Substances Data)

Upstream product

• 872-85-5 pyridine-4-carbaldehyde 
• 141-43-5 ethanolamine 

Downstream Products

• 70206-50-7 2-((pyridine-4-ylmethyl)amino)ethanol 
• 917890-17-6 C₂₂H₂₆ClN₃O₄ 

Relevant articles and documents

Multicomponent synthesis of dihydrobenzoxazepinones by coupling Ugi and Mitsunobu reactions

Various dihydrobenzo[f][1,4]oxazepin-5-ones have been convergently prepared in 2-3 steps by coupling Ugi and Mitsunobu reactions. Two alternative methodologies were used: in the first one the Ugi condensation was followed by a Mitsunobu cyclization (2 ste

Structural studies on bioactive compounds. 34.1 Design, synthesis, and biological evaluation of triazenyl-substituted pyrimethamine inhibitors of Pneumocystis carinii dihydrofolate reductase

The triazenyl-pyrimethamine derivative 3a (TAB), a potent and selective inhibitor of Pneumocystis carinii DHFR, was selected as the starting point for a lead optimization study. Molecular modeling studies, corroborated by a recent crystal structure determination of the ternary complex of P. carinii DHFR-NADPH bound to TAB, predicted that modifications to the acetoxy residue of the lead inhibitor could exploit binding opportunities in the vicinity of an active site pocket bounded by residues Ile33, Lys37, and Leu72. Substitutions in the benzyl moiety with electron-donating and electron-withdrawing groups were predicted to probe face-edge interactions with amino acid Phe69 unique to the P. carinii enzyme. New triazenes 10a-v and 12a-f were prepared by coupling the diazonium tetrafluoroborate salt 6b of aminopyrimethamine with substituted benzylamines or phenethylamines. The most potent of the new inhibitors against P. carinii DHFR was the naphthylmethyl-substituted triazene 10t (IC50: 0.053 μM), but a more substantial increase in potency against the rat liver DHFR led to a reduction in selectivity (ratio rat liver DHFR IC50/P. carinii DHFR IC50: 5.36) compared to the original lead structure 3a (ratio rat liver DHFR IC50/P. carinii DHFR IC50: 114).

HYDROGENATION OF 3,4-PYRIDYLIDENE AMINOETHANOLS AND FLOTATION PROPERTIES OF THE PRODUCTS OF THEIR REDUCTION

2-(Pyridylmethylene amino)ethanols A-(HOCH2CH2CH2N=CH)C5H4N were obtained by condensation of 3- and 4-pyridinealdehydes with monoethanolamine.IR and PMR spectra are quoted for the substances obtained, as well as data on their application in flotation of lead-zinc ore.By hydrogenation on Raney nickel at 65 deg C and 70 atm hydrogen pressure 2-(pyridylmethyl amino) ethanols A-(HOCH2CH2NHCH2)C5H4N were obtained.