Discovery of inhibitors of Escherichia coli methionine aminopeptidase with the Fe(II)-form selectivity and antibacterial activity
Methionine aminopeptidase (MetAP) is a promising target to develop novel antibiotics, because all bacteria express MetAP from a single gene that carries out the essential function of removing N-terminal methionine from nascent proteins. Divalent metal ion
Wang, Wen-Long,Chai, Sergio C.,Huang, Min,He, Hong-Zhen,Hurley, Thomas D.,Ye, Qi-Zhuang
experimental part
p. 6110 - 6120
(2009/10/23)
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