106976-24-3

Basic information

• Product Name: 2-AMino-5-broMo-4-Methylbenzoic acid
• Synonyms: 2-AMino-5-broMo-4-Methylbenzoic acid;5-bromo-4-methylanthranilic acid
• CAS NO: 106976-24-3
• Molecular Formula: C₈H₈BrNO₂
• Molecular Weight: 230.05862
• Mol File: 106976-24-3.mol

Chemical Properties

• Boiling Point: 359.8±42.0 °C(Predicted)
• Appearance: /
• Density: 1.682±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 4.72±0.10(Predicted)
• CAS DataBase Reference: 2-AMino-5-broMo-4-Methylbenzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMino-5-broMo-4-Methylbenzoic acid(106976-24-3)
• EPA Substance Registry System: 2-AMino-5-broMo-4-Methylbenzoic acid(106976-24-3)

Safety Data

• Hazardous Substances Data: 106976-24-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Research:
2-Amino-5-bromo-4-methylbenzoic acid is used as a building block for the synthesis of more complex molecules, particularly in the development of new drugs. Its unique structure and potential bioactive properties make it a valuable compound for creating innovative pharmaceutical agents.
Used in Organic Synthesis:
In the field of organic synthesis, 2-Amino-5-bromo-4-methylbenzoic acid serves as a reagent in various chemical reactions. Its versatility and reactivity contribute to the synthesis of a wide range of organic compounds, further expanding its applications in the chemical industry.

Upstream product

• 106976-23-2 5-bromo-6-methylindoline-2,3-dione 
• 6933-10-4 amino-5-bromo-2-toluene 
• 106987-81-9 4-bromo-3-methylisonitrosoacetanilide 
• 64818-80-0 2-amino-4-methylbenzoic acid ethyl ester 
• 2305-36-4 4-methylanthranilic acid 
• 79043-90-6 ethyl 2-acetamido-4-methylbenzoate 

Downstream Products

• 106976-25-4 2-(acetylamino)-5-bromo-4-methylbenzoic acid 
• 34545-25-0 2,3-diamino-4-methylbenzoic acid 
• 106976-27-6 5-bromo-4-methyl-3-nitroanthranilic acid 
• 106976-26-5 2-(acetylamino)-5-bromo-4-methyl-3-nitrobenzoic acid 
• 943605-85-4 6-bromo-7-methylquinazolin-4(3H)-one 
• 124340-71-2 7-Methyl-2-phenyl-1H-benzoimidazole-4-carboxylic acid (2-dimethylamino-ethyl)-amide 
• 124340-99-4 2-phenyl-7-methyl-1H-benzimidazole-4-carboxylic acid 

Relevant articles and documents

DUAL ATM AND DNA-PK INHIBITORS FOR USE IN ANTI-TUMOR THERAPY

Provided herein are compounds of the Formula (I), (II), and (III), as well as pharmaceutically acceptable salts thereof, wherein the substituents are those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of oncologic diseases.

HETEROCYCLIC COMPOUNDS USEFUL AS MODULATORS OF ACETYLCHOLINE RECEPTORS

The present invention aims to provide a compound that may be useful for the prophylaxis or treatment of constipation and the like. The present invention provides a compound represented by the following formula (I) : wherein each symbol is as described in the specification, salt thereof.

Novel Fused Arylpyrimidinone Based Allosteric Modulators of the M1 Muscarinic Acetylcholine Receptor

Benzoquinazolinone 1 is a positive allosteric modulator (PAM) of the M1 muscarinic acetylcholine receptor (mAChR), which is significantly more potent than the prototypical PAM, 1-(4-methoxybenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (BQCA). In this study, we explored the structural determinants that underlie the activity of 1 as a PAM of the M1 mAChR. We paid particular attention to the importance of the tricyclic scaffold of compound 1, for the activity of the molecule. Complete deletion of the peripheral fused benzene ring caused a significant decrease in affinity and binding cooperativity with acetylcholine (ACh). This loss of affinity was rescued with the addition of either one or two methyl groups in the 7- and/or 8-position of the quinazolin-4(3H)-one core. These results demonstrate that the tricyclic benzo[h]quinazolin-4(3H)-one core could be replaced with a quinazolin-4(3H)-one core and maintain functional affinity. As such, the quinazolin-4(3H)-one core represents a novel scaffold to further explore M1 mAChR PAMs with improved physicochemical properties.

QUINAZOLINEDIONE DERIVATIVE

The present invention relates to quinazolinedione derivatives represented by formula (I) or pharmaceutically acceptable salts thereof.

Substituted 4-Amino-Quinazoline Compounds with Metabotropic Glutamate Receptor Regulating Activity and Uses Thereof

Substituted 4-amino-quinazoline compounds corresponding to formula I methods for their production, pharmaceutical compositions containing these compounds as active agents, and the uses thereof for treating or inhibiting disorders or disease states.

Potential Antitumor Agents. 59. Structure-Activity Relationships for 2-Phenylbenzimidazole-4-carboxamides, a New Class of "Minimal" DNA-Intercalating Agents Which May Not Act via Topoisomerase II

A series of substituted 2-phenylbenzimidazole-4-carboxamides has been synthesized and evaluated for in vitro and in vivo antitumor activity.These compounds represent the logical conclusion to our search for "minimal" DNA-intercalating agents with the lowest possible DNA-binding constants.Such "2-1" tricyclic chromophores, of lower aromaticity than the structurally similar 2-phenylquinolines, have the lowest DNA binding affinity yet seen in the broad series of tricyclic carboxamide intercalating agents.Despite very low in vitro cytotoxicities, several of the compoundshad moderate levels of in vivo antileukemic effects.However, the most interesting aspect of their biological activity was the lack of cross-resistance shown to an amsacrine-resistant P388 cell line, suggesting that these compounds may not express their cytotoxicity via interaction with topoisomerase II.