DIPEPTIDYL PEPTIDASE-IV INHIBITING COMPOUNDS, METHODS OF PREPARING THE SAME, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AS AN ACTIVE AGENT
The present invention relates to novel compounds exhibiting good inhibitory activity versus Dipeptidyl Peptidase-IV(DPP-IV), methods of preparing the same and pharmaceutical compositions containing the same as an active agent.
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(2010/11/24)
Preparation of 2-n-propyl-4-amino-5-methoxymethyl-pyrimidine
In an improved process for the preparation of 2-n-propyl-4-amino-5-methoxymethyl-pyrimidine of the formula I STR1 by reacting butyramidine II STR2 with α-methoxymethyl-β-methoxyacrylonitrile III STR3 the butyramidine II is reacted with a 0.4-5 molar excess of α-methoxymethyl-β-methoxyacrylonitrile III at from -10° to +20° C.