- 6-hydroxy-8-chloro ethyl caprylate preparation method thereof
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The present invention discloses a preparation method of a lipoic acid key intermediate 6-hydroxy-8-chloro ethyl caprylate having a structure formula represented by a formula (I), wherein 6-oxo-8-chloro ethyl caprylate having a structure represented by a formula (II) is adopted as a starting raw material and is reduced to prepare the 6-hydroxy-8-chloro ethyl caprylate. Compared to the preparation method in the prior art, the preparation method of the present invention mainly has the following advantages that the synthesis steps are simple, the use of the organic solvent is reduced, the direction discharging of the wastewater is avoided, the generated sodium metaborate is easily separated and cannot react with other substances, the sodium metaborate solid is successfully recovered, and the ammonia water is recovered and utilized; particularly by recovering the sodium metaborate, the possibility is created for the recycling of the boron element through the sodium borohydride preparation with the further industrial recovery of the boron element; and the whole process meets the green synthesis and cleaning production technology requirement, and is suitable for the large-scale industrial production. The formulas (I) and (II) are defined in the specification.
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Paragraph 0019
(2017/08/29)
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