- Antiandrogenic steroidal sulfonylpyrazoles
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The steroidal sulfonylpyrazole 1 bound to the rat ventral prostate androgen receptor in vitro; it inhibited testosterone propionate induced increases in ventral prostate weight in vivo in the castrated, immature male rat with an ED50 of 15 mg/k
- Christiansen,Bell,D'Ambra,Mallamo,Herrmann,Ackerman,Opalka,Kullnig,Winneker,Snyder,Batzold,Schane
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p. 2094 - 2100
(2007/10/02)
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- Antiandrogenic sulfonylsteroidopyrazoles and processes for preparation method of use and compositions thereof
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1''-Sulfonylsteroido[3,2-c]pyrazoles, for example, (5α,17α)-1''-(methylsulfonyl)-1''H-pregn-20-yno[3,2-c]pyrazol-17-ol, which are useful as antiandrogenic agents, and processes for preparation, method of use and compositions thereof are disclosed.
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