107028-32-0

Basic information

• Product Name: 4'-BROMO-2-(4-FLUOROPHENYL)ACETOPHENONE
• Synonyms: 4'-BROMO-2-(4-FLUOROPHENYL)ACETOPHENONE;UKRORGSYN-BB BBV-5118721
• CAS NO: 107028-32-0
• Molecular Formula: C14H10BrFO
• Molecular Weight: 293.13
• Mol File: 107028-32-0.mol

Chemical Properties

• Boiling Point: 387.6°C at 760 mmHg
• Flash Point: 188.2°C
• Appearance: /
• Density: 1.45g/cm³
• Vapor Pressure: 3.27E-06mmHg at 25°C
• Refractive Index: 1.592
• CAS DataBase Reference: 4'-BROMO-2-(4-FLUOROPHENYL)ACETOPHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 4'-BROMO-2-(4-FLUOROPHENYL)ACETOPHENONE(107028-32-0)
• EPA Substance Registry System: 4'-BROMO-2-(4-FLUOROPHENYL)ACETOPHENONE(107028-32-0)

Safety Data

• Hazardous Substances Data: 107028-32-0(Hazardous Substances Data)

Usage

InChI:InChI=1/C14H10BrFO/c15-12-5-3-11(4-6-12)14(17)9-10-1-7-13(16)8-2-10/h1-8H,9H2

Upstream product

• 2039-82-9 1-bromo-4-ethenyl-benzene 
• 459-45-0 4-fluorobenzenediazonium tetrafluoroborate 
• 459-22-3 4-fluorophenylacetonitrile 
• 5467-74-3 4-Bromophenylboronic acid 

Relevant articles and documents

Two-Step One-Pot Synthesis of Unsymmetrical (Hetero)Aryl 1,2-Diketones by Addition-Oxygenation of Potassium Aryltrifluoroborates to (Hetero)Arylacetonitriles

An efficient one-pot two-step procedure for the synthesis of unsymmetrical (hetero)aryl 1,2-diketones has been developed. The reaction proceeds through a palladium-catalyzed nucleophilic addition of potassium aryltrifluoroborates to aliphatic nitriles followed by a copper-catalyzed aerobic benzylic C–H oxygenation using molecular oxygen as a green oxidant. This represents the first example of the direct synthesis of unsymmetrical diaryl 1,2-diketones from arylacetonitriles. This method utilizes inexpensive, stable, nontoxic, and readily available starting materials, is highly effective in the presence of both electron-rich and electron-poor nitriles and aryltrifluoroborates, and tolerates a wide variety of functional groups. The synthetic utility of this transformation was shown by increasing the scale of the reaction and by carrying out the one-pot protocol for the preparation of quinoxaline and benzimidazole derivatives. A plausible reaction mechanism has also been proposed.

Ascorbic Acid Promoted Oxidative Arylation of Vinyl Arenes to 2-Aryl Acetophenones without Irradiation at Room Temperature under Aerobic Conditions

A convenient and general protocol for oxidative arylation of vinyl arenes by aryl radicals generated in situ from arene diazonium fluoroborates promoted by ascorbic acid in air at room temperature has been developed in the absence of any additive and visible light irradiation. A series of diversely substituted 2-aryl acetophenones have been obtained in good yields by this procedure.