107036-56-6

Basic information

• Product Name: 2',3'-dideoxy-5-methylcytidine
• Synonyms: 2',3'-dideoxy-5-methylcytidine
• CAS NO: 107036-56-6
• Molecular Formula: C10H15N3O3
• Molecular Weight: 225.2444
• Mol File: 107036-56-6.mol

Chemical Properties

• Boiling Point: 416.8°Cat760mmHg
• Flash Point: 205.9°C
• Appearance: /
• Density: 1.51g/cm³
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility: DMSO (Slightly), Methanol (Slightly), Water (Slightly)
• CAS DataBase Reference: 2',3'-dideoxy-5-methylcytidine(CAS DataBase Reference)
• NIST Chemistry Reference: 2',3'-dideoxy-5-methylcytidine(107036-56-6)
• EPA Substance Registry System: 2',3'-dideoxy-5-methylcytidine(107036-56-6)

Safety Data

• Hazardous Substances Data: 107036-56-6(Hazardous Substances Data)

Upstream product

• 153864-70-1 2,2-Dimethyl-propionic acid (2R,3R,5R)-5-(4-amino-5-methyl-2-oxo-2H-pyrimidin-1-yl)-3-chloro-tetrahydro-furan-2-ylmethyl ester 
• 153864-71-2 2,2-Dimethyl-propionic acid (2R,3S,5R)-5-(4-amino-5-methyl-2-oxo-2H-pyrimidin-1-yl)-3-chloro-tetrahydro-furan-2-ylmethyl ester 
• 153864-66-5 2,2-Dimethyl-propionic acid (2R,3R,5R)-3-chloro-5-(4-chloro-5-methyl-2-oxo-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester 
• 153864-67-6 2,2-Dimethyl-propionic acid (2R,3S,5R)-3-chloro-5-(4-chloro-5-methyl-2-oxo-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester 
• 7791-71-1 5'-O-tritylthymidine 
• 107036-53-3 3'-O-(1-imidazolylthiocarbonyl)-5'-O-tritylthymidine 
• 107036-54-4 3'-deoxy-5'-O-triphenylmethylthymidine 
• 40733-25-3 2'-deoxy-5'-O-pivaloylthymidine 
• 120826-44-0 2',3'-didehydro-2',3'-dideoxy-5-methylcytidine 
• 107036-55-5 2',3'-dideoxy-5'-O-(tritylribosyl)-5-methyl-4-(1,2,4-triazol-1-yl)pyrimidin-2-one 

Relevant articles and documents

Improved synthesis of 2',3'-dideoxycytidine (d2C) and its correlated nucleoside analogues

2',3'-deoxy and 2',3'-dideoxy-2',3'-didehydrocytidine (d2C and d4C) have been synthesized in good yields from 2'-deoxyuridine via dichlorinated derivatives 7a-b. The same synthetic strategy was used in the synthesis of d2C(Me) and d4C(Me) from thymidine. Following this method the evaluable 3'-chloro-2'-deoxycytidine derivatives 9-12 can be easily obtained.

5-substituted-2',3'-dideoxycytidine compounds with anti-HTLV-III activity

5-substituted 2',3'-dideoxycytidine compounds and their monophosphates are disclosed which have been found to have potent activity against retroviruses. The 5-fluoro-and 5-aza-substituted 2',3'-dideoycytidine compounds have been found to be effective against HTLV-III/LAV virus.

Potent Anti-AIDS Drugs. 2',3'-Dideoxycytidine Analogues

5-Substituted 2',3'-dideoxycytidine analogues have been synthesized and evaluated in vitro for their capabilities to protect T4+ lymphocytes from the cytopathic effects of the HTLV-III/LAV (HIV) virus, the causative agent of acquired immunodefi