Discovery and X-ray crystallographic analysis of a spiropiperidine iminohydantoin inhibitor of β-secretase
A high-throughput screen at 100 μM inhibitor concentration for the BACE-1 enzyme revealed a novel spiropiperidine iminohydantoin aspartyl protease inhibitor template. An X-ray cocrystal structure with BACE-1 revealed a novel mode of binding whereby the in
Barrow, James C.,Stauffer, Shaun R.,Rittle, Kenneth E.,Ngo, Phung L.,Yang, ZhiQiang,Selnick, Harold G.,Graham, Samuel L.,Munshi, Sanjeev,McGaughey, Georgia B.,Holloway, M. Katharine,Simon, Adam J.,Price, Eric A.,Sankaranarayanan, Sethu,Colussi, Dennis,Tugusheva, Katherine,Lai, Ming-Tain,Espeseth, Amy S.,Xu, Min,Huang, Qian,Wolfe, Abigail,Pietrak, Beth,Zuck, Paul,Levorse, Dorothy A.,Hazuda, Daria,Vacca, Joseph P.
supporting information; experimental part
p. 6259 - 6262
(2009/10/17)
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