107091-89-4

Basic information

• Product Name: THIAZOLE ORANGE
• Synonyms: 1-METHYL-4-[(3-METHYL-2(3H)-BENZOTHIAZOLYLIDENE)METHYL]QUINOLINIUM P-TOSYLATE;THIAZOLE ORANGE, FOR FLUORESCENCE;Quinolinium, 1-methyl-4-((3-methyl-2(3H)-benzothiazolylidene)methyl)-, salt with 4-methylbenzenesulfonic acid (1:1);Thiazol Orange;(Z)-1-Methyl-4-((3-Methylbenzo[d]thiazol-2(3H)-ylidene)Methyl)quinolin-1-iuM 4-Methylbenzenesulfonate;THIAZOLE ORANGE;Thiazole orange *10 mM in DMSO*;Thiazole orange *CAS 107091-89-4*
• CAS NO: 107091-89-4
• Molecular Formula: C₇H₇O₃S*C₁₉H₁₇N₂S
• Molecular Weight: 476.61
• Mol File: 107091-89-4.mol

Chemical Properties

• Melting Point: 270 °C (dec.)(lit.)
• Appearance: /
• Solubility: DMSO: soluble
• CAS DataBase Reference: THIAZOLE ORANGE(CAS DataBase Reference)
• NIST Chemistry Reference: THIAZOLE ORANGE(107091-89-4)
• EPA Substance Registry System: THIAZOLE ORANGE(107091-89-4)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• F: 8-10
• Hazardous Substances Data: 107091-89-4(Hazardous Substances Data)

Usage

Uses

Used in Biomedical Research:
Thiazole Orange is used as a nucleic acid stain for reticulocyte analysis, Plasmodium species analysis, and labeling cancer cells. It aids in the identification and quantification of these cells, contributing to the understanding of various diseases and conditions.
Used in Flow Cytometry:
Thiazole Orange is used as a fluorescent DNA staining dye in flow cytometry for analyzing reticulocytes and other cell populations. Its fluorescence properties allow for the rapid and accurate assessment of cell characteristics.
Used in Gel Electrophoresis:
In agarose gel electrophoresis, Thiazole Orange is used to stain DNA or RNA, providing a visual means to assess the size, quantity, and integrity of nucleic acid samples.
Used in Capillary Electrophoresis:
Thiazole Orange is also utilized as a fluorescent DNA staining dye in capillary electrophoresis, enabling the separation and detection of DNA fragments with high sensitivity and resolution.
Overall, Thiazole Orange is a valuable tool in the fields of molecular biology, cell biology, and medical diagnostics, owing to its ability to stain and visualize nucleic acids in various experimental setups.

InChI:InChI=1/C19H17N2S.C7H8O3S/c1-20-12-11-14(15-7-3-4-8-16(15)20)13-19-21(2)17-9-5-6-10-18(17)22-19;1-6-2-4-7(5-3-6)11(8,9)10/h3-13H,1-2H3;2-5H,1H3,(H,8,9,10)/q+1;/p-1

Related news

Adenosine triphosphate-selective fluorescent turn-on response of a novel THIAZOLE ORANGE (cas 107091-89-4) derivative via their cooperative co-assembly08/17/2019

A novel thiazole orange (TO) derivative 3 has been synthesized and it could give the fluorescence turn-on responsive signal upon binding to nucleotides and besides, it exhibits high selectivity toward adenosine triphosphate (ATP) over other tested nucleotides. The nonlinear sigmoidal-responded p...detailed

Synthesis of chloro-substituted analogs of THIAZOLE ORANGE (cas 107091-89-4) – Fluorophores for flow cytometric analyses08/16/2019

Synthesis, absorption and fluorescence properties of a series of asymmetrical monomethine cyanine dyes, chloro-containing analogs of Thiazole orange, are reported. Their staining ability was studied by flow cytometry. The saturating concentrations of each dye that gives a stable staining intensi...detailed

THIAZOLE ORANGE (cas 107091-89-4) as a fluorescent probe: Label-free and selective detection of silver ions based on the structural change of i-motif DNA at neutral pH08/15/2019

Silver ions have been widely applied to many fields and have harmful effects on environments and human health. Herein, a label-free optical sensor for Ag+ detection is constructed based on thiazole orange (TO) as a fluorescent probe for the recognition of i-motif DNA structure change at neutral ...detailed

Ebola virus derived G-quadruplexes: THIAZOLE ORANGE (cas 107091-89-4) interaction08/13/2019

The Ebola and Marburg viruses are some of the deadliest viruses in the world. In this study a series of G-rich DNA sequences derived from these types of viruses which possess the potential to form G-quadruplex structures are analyzed. A set of DNA oligonucleotides derived from original viral iso...detailed

A simple structural modification to THIAZOLE ORANGE (cas 107091-89-4) to improve the selective detection of G-quadruplexes08/12/2019

Thiazole orange is a commonly used cyanine dye for binding to nucleic acids. Recently, it has been used for the detection of G-quadruplexes. However, thiazole orange is non-selective for G-quadruplex and other nucleic acids, thus hampering its further application. Herein, we designed and synthes...detailed

A series of modified THIAZOLE ORANGE (cas 107091-89-4) dye as the highly fluorescent G-quadruplex DNA binders: The study of electronic effects of the substituent on 1-methylquinolinium moiety08/11/2019

The molecular of scaffold of thiazole orange has a number of merits for being as a fluorescent dye with tailor-made structure advancement for many useful applications. Structural modification based on 1-methylquinolinium moiety of thiazole orange is able to induce critical effects on fluorescent...detailed

THIAZOLE ORANGE (cas 107091-89-4) – Spermine conjugate: A potent human telomerase inhibitor comparable to BRACO-1908/10/2019

In this report, we synthesized a series of TO conjugates containing different amino side chains and investigated their binding to telomeric G-quadruplex DNA (G4) using several biophysical methods including fluorometric titration and thermal denaturation monitored by fluorescence and circular dic...detailed

Relevant articles and documents

Formation of linear supramolecular polymers that is based on host-guest assembly in water

Cucurbit[n]urils (n = 7, 8) and thiazole orange (TO) dyes in aqueous media were found to form host-guest inclusions in different stoichiometries. Supramolecular structures and linear supramolecular polymers were observed through the hydrophobic effect and π-π interactions in aqueous solution.