Novel, potent, selective, and metabolically stable stearoyl-CoA desaturase (SCD) inhibitors
We identified a series of structurally novel SCD (Δ9 desaturase) inhibitors via high-throughput screening and follow-up SAR studies. Modification of the central bicyclic scaffold has proven key to our potency optimization effort. The most potent analog (8
Koltun, Dmitry O.,Parkhill, Eric Q.,Vasilevich, Natalya I.,Glushkov, Andrei I.,Zilbershtein, Timur M.,Ivanov, Alexei V.,Cole, Andrew G.,Henderson, Ian,Zautke, Nathan A.,Brunn, Sandra A.,Mollova, Nevena,Leung, Kwan,Chisholm, Jeffrey W.,Zablocki, Jeff
scheme or table
p. 2048 - 2052
(2009/11/30)
More Articles about upstream products of 1071526-28-7