- Synthesis of new pyrazolo[1,5-a]pyrimidines by reaction of β,γ-unsaturated γ-alkoxy-α-keto esters with N-unsubstituted 5-aminopyrazoles
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The reaction of β,γ-unsaturated γ-alkoxy-α-keto esters with N-unsubstituted 5-aminopyrazoles was investigated. The reaction proceeds with high regioselectivity and is considered as an effective- method for the preparation of new pyrazolo[1,5-a]pyrimidines bearing an ester function in the 7-position. The obtained drug-like compounds have a great potential for medicinal chemistry as they closely resemble the structure of several marketed pharmaceuticals. Georg Thieme Verlag Stuttgart - New York.
- Stepaniuk, Oleksandr O.,Matviienko, Vitalii O.,Kondratov, Ivan S.,Vitruk, Igor V.,Tolmachev, Andrei O.
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supporting information
p. 925 - 930
(2013/05/09)
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- PREPARATION OF SUBSTITUTED-4,5-DIHYDROPYRROLO[4,3,2-de][2,6]NAPHTHYRIDIN-3(1H)-ONES
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Disclosed are materials and methods for preparing substituted 4,5-dihydropyrrolo[4,3,2-de][2,6]naphthyridin-3(1H)-ones of formula (1), Compounds of formula (1) inhibit one or more members of the Janus Kinase (JAK) family of cytoplasmic protein tyrosine kinases, and are useful for treating disorders, diseases, and conditions associated with the immune system, inflammation, and abnormal cell growth.
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(2012/06/30)
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