- Improved specific radioactivity of the PET radioligand [11C]FLB 457 by use of the GE Medical Systems PETtrace MeI MicroLab
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[11C]FLB 457 is a high affinity dopamine D2 receptor radioligand that is used for visualisation and quantitation of extrastriatal dopamine D2 receptors with positron emission tomography (PET). In this study, we report a co
- Sandell, Johan,Langer, Oliver,Larsen, Peter,Dolle, Frederic,Vaufrey, Francoise,Demphel, Stephane,Crouzel, Christian,Halldin, Christer
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Read Online
- Pyrrolidine compounds, salts thereof, applications of compounds or salts thereof in nuclear magnetic probes and medicines, reagent, and medicine
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The invention provides pyrrolidine compounds, salts thereof, applications of the compounds or the salts thereof in nuclear magnetic probes and medicines, a reagent, and a medicine. The benzamide methylpyrrolidine compounds have a chemical structure represented by general formula (I); and in the formula (I), R is selected from a methyl group, an ethyl group, a methoxy group, an ethoxy group and halogen, R is selected from a methyl group, an ethyl group, a methoxy group, an ethoxy group and halogen, R is selected from C1-5 alkyl groups and H, X is selected from C1-10 alkylene groups or is deleted, X is selected from -(CH2CH2O)n- (n is 1-5) or is deleted, X is selected from C1-5 alkyl groups, X is selected from oxygen, sulfur and a methylene group, and Ln is selected from Gd and Eu. The compounds have a gadolinium and europium chelating structure formed by combining with a dopamine D2 receptor and depending on intramolecular chelating groups, and specifically enhance the contrast of dopamine D2 receptor expression tissues on images in magnetic resonance imaging.
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Paragraph 0242; 0243; 0244
(2017/08/27)
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- Facile preparation of (S)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2,3-dimethoxy-5- (tributyltin)benzamide from isoremoxipiride: The precursor of [125I]- and [123I]epidepride
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[125I]Epidepride, (S)-(-)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-5-[125I]iodo-2,3- dimethoxybenzamide ([125I]NCQ 219), is a new, extremely potent radioligand, useful in the study of the distribution of the dopamine D-2 recepto
- De Paulis,Smith
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p. 1091 - 1095
(2007/10/02)
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- Potential antipsychotic agents. 7. Synthesis and antidopaminergic properties of the atypical highly potent (S)-5-bromo-2,3-dimethoxy-N-[(1-ethyl-2-pyrrolidinyl)methyl]benzamide and related compounds. A comparative study
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(S)-5-Bromo-2,3-dimethoxy-N-[(1-ethyl-2-pyrrolidinyl)methyl]benzamide (6) and some related compounds, i.e. the R isomer 7, the 3-hydroxy analogue 8, the desbromo derivative 9, the monomethoxy compound 10, and the 2,4-dimethoxy analogue 11, have been synth
- Hogberg,De Paulis,Johansson,Kumar,Hall,Ogren
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p. 2305 - 2309
(2007/10/02)
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