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CAS

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1072951-54-2

2,6-Dichloropyridine-4-boronic acid is an organic compound with the molecular formula C5H4BCl2NO2. It is a derivative of pyridine, a heterocyclic compound with a nitrogen atom in the ring structure. The presence of two chlorine atoms at the 2nd and 6th positions, along with a boronic acid group at the 4th position, gives this compound unique chemical properties and reactivity.

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  • 1072951-54-2 Structure

  • Basic information

    1. Product Name: 2,6-Dichloropyridine-4-boronicacid
    2. Synonyms: 2,6-Dichloropyridine-4-boronicacid;2,6-DICHLOROPYRIDIN-4-YLBORONIC ACID;6-dichloropyridin-4-yl-4-boronic acid
    3. CAS NO:1072951-54-2
    4. Molecular Formula: C5H4BCl2NO2
    5. Molecular Weight: 191.80776
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1072951-54-2.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 396.783 °C at 760 mmHg
    3. Flash Point: 193.768 °C
    4. Appearance: off-white solid
    5. Density: 1.567 g/cm3
    6. Refractive Index: N/A
    7. Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
    8. Solubility: N/A
    9. PKA: 5.57±0.11(Predicted)
    10. CAS DataBase Reference: 2,6-Dichloropyridine-4-boronicacid(CAS DataBase Reference)
    11. NIST Chemistry Reference: 2,6-Dichloropyridine-4-boronicacid(1072951-54-2)
    12. EPA Substance Registry System: 2,6-Dichloropyridine-4-boronicacid(1072951-54-2)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1072951-54-2(Hazardous Substances Data)

1072951-54-2 Usage

Uses

Used in Pharmaceutical Industry:
2,6-Dichloropyridine-4-boronic acid is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique chemical structure allows it to be a versatile building block for the development of new drugs with specific therapeutic applications.
Used in Diabetes Treatment:
In the field of diabetes treatment, 2,6-Dichloropyridine-4-boronic acid is used as a starting material for the preparation of orally bioavailable GPR40 agonists bearing a thiophenylpropanoic acid scaffold. GPR40 is a receptor that plays a role in glucose homeostasis, and its agonists have been shown to improve insulin secretion and glucose tolerance in diabetic patients. By incorporating 2,6-Dichloropyridine-4-boronic acid into the molecular structure of these agonists, researchers can develop more effective and safer treatments for diabetes.

Check Digit Verification of cas no

The CAS Registry Mumber 1072951-54-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,7,2,9,5 and 1 respectively; the second part has 2 digits, 5 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1072951-54:
(9*1)+(8*0)+(7*7)+(6*2)+(5*9)+(4*5)+(3*1)+(2*5)+(1*4)=152
152 % 10 = 2
So 1072951-54-2 is a valid CAS Registry Number.

1072951-54-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name (2,6-Dichloropyridin-4-yl)boronic acid

1.2 Other means of identification

Product number -
Other names (2,6-dichloropyridin-4-yl)boronic acid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1072951-54-2 SDS

1072951-54-2Upstream product

1072951-54-2Relevant articles and documents

SUBSTITUTED HETEROCYCLIC SULFONAMIDE COMPOUNDS USEFUL AS TRPA1 MODULATORS

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Paragraph 0773; 0774, (2015/04/28)

The invention is concerned with the compounds of formula I or II: and salts thereof. In addition, the present invention relates to methods of manufacturing and methods of using the compounds of formula I or II as well as pharmaceutical compositions containing such compounds. The compounds may be useful in treating diseases and conditions mediated by TRPA1, such as pain.

Hydrolytic stability of nitrogenous-heteroaryltrifluoroborates under aqueous conditions at near neutral pH

Li, Ying,Asadi, Ali,Perrin, David M.

experimental part, p. 377 - 382 (2009/12/04)

The hydrolytic stability of heteroaryltrifluoroborates under physiological conditions has been analyzed by 19F NMR spectroscopy and is found to be greatly enhanced by the presence of endocyclic ring nitrogens. Stability is further enhanced by the presence of exocyclic electron withdrawing substituents. As with aryltrifluoroborates, NMR analysis suggests that the hydrolysis proceeds via single rate-determining step reflecting loss of the first fluoride atom. The stability of these complexes is significant both in terms of metal catalyzed cross-coupling reactions as well as the potential for generating boronic acid based 18F-PET imaging agents.

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