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CAS

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1073160-26-5

PF 04554878 hydrochloride is a novel, potent, and selective inhibitor of the fatty acid amide hydrolase (FAAH) enzyme, which is crucial in endocannabinoid signaling and metabolism. It effectively increases the levels of the endocannabinoid anandamide, known for its anti-inflammatory and analgesic properties. With its high selectivity for FAAH, it minimizes off-target effects and has shown favorable safety and pharmacokinetic profiles, positioning it as a promising candidate for the development of new medications.

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  • 1073160-26-5 Structure

  • Basic information

    1. Product Name: PF 04554878 hydrochloride
    2. Synonyms: Defactinib hydrochloride;PF 04554878 hydrochloride;PF04554878 hydrochloride;PF-04554878 hydrochloride;VS 6063 hydrochloride;VS6063 hydrochloride;VS-6063 hydrochloride;Defactinib( VS-6063,PF-04554878 ) hydrochloride
    3. CAS NO:1073160-26-5
    4. Molecular Formula: C20H21F3N8O3S*ClH
    5. Molecular Weight: 546.9536896
    6. EINECS: N/A
    7. Product Categories: API
    8. Mol File: 1073160-26-5.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: PF 04554878 hydrochloride(CAS DataBase Reference)
    10. NIST Chemistry Reference: PF 04554878 hydrochloride(1073160-26-5)
    11. EPA Substance Registry System: PF 04554878 hydrochloride(1073160-26-5)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1073160-26-5(Hazardous Substances Data)

1073160-26-5 Usage

Uses

Used in Pharmaceutical Industry:
PF 04554878 hydrochloride is used as a therapeutic agent for the treatment of various conditions, including chronic pain, inflammation, and psychiatric disorders. Its ability to modulate endocannabinoid signaling offers a potential avenue for managing these conditions with reduced side effects compared to traditional treatments.
Used in Pain Management:
PF 04554878 hydrochloride is used as an analgesic agent to alleviate chronic pain by increasing the levels of anandamide, which interacts with the endocannabinoid system to produce pain-relieving effects.
Used in Inflammation Control:
PF 04554878 hydrochloride is used as an anti-inflammatory agent to reduce inflammation by modulating the endocannabinoid system, which plays a role in the body's inflammatory response.
Used in Psychiatric Disorders Treatment:
PF 04554878 hydrochloride is used as a psychiatric treatment to address various mental health conditions by leveraging the endocannabinoid system's influence on mood, anxiety, and other cognitive functions.
Used in Drug Development Research:
PF 04554878 hydrochloride is used as a research tool in the development of new medications targeting the endocannabinoid system for a range of therapeutic applications, given its high selectivity and favorable safety profile.

Check Digit Verification of cas no

The CAS Registry Mumber 1073160-26-5 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,7,3,1,6 and 0 respectively; the second part has 2 digits, 2 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1073160-26:
(9*1)+(8*0)+(7*7)+(6*3)+(5*1)+(4*6)+(3*0)+(2*2)+(1*6)=115
115 % 10 = 5
So 1073160-26-5 is a valid CAS Registry Number.

1073160-26-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name N-methyl-4-[[4-[[3-[methyl(methylsulfonyl)amino]pyrazin-2-yl]methylamino]-5-(trifluoromethyl)pyrimidin-2-yl]amino]benzamide,hydrochloride

1.2 Other means of identification

Product number -
Other names VS-6063

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1073160-26-5 SDS

1073160-26-5Downstream Products

1073160-26-5Relevant articles and documents

SULFONYL AMIDE DERIVATIVES FOR THE TREATMENT OF ABNORMAL CELL GROWTH

-

Page/Page column 53, (2009/04/24)

The present invention relates to a compound of the formula I wherein R1 to R6, A, B, n and m are as defined herein. Such novel sulfonyl amide derivatives are useful in the treatment of abnormal cell growth, such as cancer, in mammals. This invention also relates to a method of using such compounds in the treatment of abnormal cell growth in mammals, especially humans, and to pharmaceutical compositions containing such compounds.

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