Substituted Heterocycles as Therapeutic agents for treating cancer
MDM2 and MDM4 proteins prevent apoptosis of cancer cells by negatively regulating the transcription factor p53. Compounds according to Formula I are selective antagonists of MDM2 and MDM4 proteins, disrupting the p53/MDM2 and p53/MDM4 complex. These compo
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Page/Page column 14-15
(2012/01/13)
Robust generation of lead compounds for protein-protein interactions by computational and MCR chemistry: P53/Hdm2 antagonists
The parallel discovery of multiple scaffolds useful to antagonize the cancer-relevant proteinprotein interaction p53/Hdm2 is described. The new method is based on the tightly interwoven interplay of multicomponent reaction chemistry, structural biology, c
Czarna, Anna,Beck, Barbara,Srivastava, Stuti,Popowicz, Grzegorz M.,Wolf, Siglinde,Huang, Yijun,Bista, Michal,Holak, Tad A.,Doemling, Alexander
supporting information; experimental part
p. 5352 - 5356
(2010/10/20)
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