- ARYL-BIPYRIDINE AMINE DERIVATIVES AS PHOSPHATIDYLINOSITOL PHOSPHATE KINASE INHIBITORS
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The invention relates to inhibitors of PI5P4K inhibitors useful in the treatment of cancers, neurodegenerative diseases, inflammatory disorders, and metabolic diseases, having the Formula (I): wherein A, X, Y, Z, Q, R1, R2, R3, R4, R5, and n are described herein.
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Paragraph 0474; 0512
(2019/07/13)
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- Method for synthesizing aminopyridine borate
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The invention discloses a method for synthesizing aminopyridine boronate. According to the method, after nitryl-halogenated pyridine is subjected to Suzuki coupling with metal palladium and bis(glycolato)diboron and simple filtration is performed, hydrogen is directly introduced for reduction, and the product is obtained. Through the operation of the method, the situation is avoided that in the product, the other half of bisdiboron removed during coupling and aminopyridine form a complex compound; the obtained product is high in purity and yield.
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Paragraph 0005; 0017-0019
(2018/07/03)
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- Imidazo [1,2-a] pyridine-6-boronic acid frequency ester and its derivatives preparation method
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The invention discloses preparation methods for imidazole[1,2-a]pyridine-6-boric acid pinacol ester and derivatives thereof. The preparation methods comprise a preparation method for imidazole[1,2-a]pyridine-6-boric acid pinacol ester, a preparation method for imidazole[1,2-a]pyridine-7-boric acid pinacol ester and a preparation method for imidazole[1,2-a]pyridine-8-boric acid pinacol ester. The imidazole[1,2-a]pyridine-6-boric acid pinacol ester and derivatives thereof prepared by using the preparation methods are used in the Suzuki coupling reaction for a coupling reaction with compounds like halides and TfO-R. According to a technical scheme in the invention, the preparation methods have the advantages of high reaction yield, easy purification, suitability for production, etc.
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Paragraph 0065-0071
(2016/10/17)
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- Aminoheteroaryl benzamides as kinase inhibitors
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The present invention provides a compound of Formula (I) or a salt thereof; and therapeutic uses of these compounds. The present invention further provides pharmaceutical compositions comprising these compounds, and compositions comprising these compounds with a therapeutic co-agent.
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Page/Page column 379; 380
(2016/02/15)
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