1073519-83-1Relevant articles and documents
N-Hydroxybenzimidazole inhibitors of ExsA MAR transcription factor in Pseudomonas aeruginosa: In vitro anti-virulence activity and metabolic stability
Grier, Mark C.,Garrity-Ryan, Lynne K.,Bartlett, Victoria J.,Klausner, Kevin A.,Donovan, Peter J.,Dudley, Caroline,Alekshun, Michael N.,Ken Tanaka,Draper, Michael P.,Levy, Stuart B.,Kim, Oak K.
supporting information; experimental part, p. 3380 - 3383 (2010/08/06)
ExsA is a multiple adaptational response (MAR) transcription factor, regulating the expression of a virulence determinant, the type III secretion system (T3SS) in Pseudomonas aeruginosa. Non-cytotoxic, non-antibacterial N-hydroxybenzimidazoles were identified as effective inhibitors of ExsA-DNA binding, and their potential utility as anti-virulence agents for P. aeruginosa was demonstrated in a whole cell assay. Select N-hydroxybenzimidazole inhibitors were stable in an in vitro human liver microsomal assay.