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(S)-Propafenone is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 107381-32-8 Structure
  • Basic information

    1. Product Name: (S)-Propafenone
    2. Synonyms: (-)-(S)-Propafenone;(S)-Propafenone;1-Propanone, 1-[2-[(2S)-2-hydroxy-3-(propylamino)propoxy]phenyl]-3-phenyl- (9CI);1-Propanone, 1-[2-[2-hydroxy-3-(propylamino)propoxy]phenyl]-3-phenyl-, (S)-;(-)-Propafenon;1-[2-[(S)-2-Hydroxy-3-(propylamino)propoxy]phenyl]-3-phenyl-1-propanone;2'-[(2S)-2-Hydroxy-3-(propylamino)propoxy]-β-phenylpropiophenone;1-[2-[(2S)-2-hydroxy-3-(propylaMino)propoxy]phenyl]-3-phenyl-
    3. CAS NO:107381-32-8
    4. Molecular Formula: C21H27NO3
    5. Molecular Weight: 341.448
    6. EINECS: N/A
    7. Product Categories: Amines;Aromatics;Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals
    8. Mol File: 107381-32-8.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 519.6°Cat760mmHg
    3. Flash Point: 268°C
    4. Appearance: /
    5. Density: 1.096g/cm3
    6. Vapor Pressure: 1.27E-11mmHg at 25°C
    7. Refractive Index: 1.557
    8. Storage Temp.: Refrigerator
    9. Solubility: Chloroform (Slightly), Methanol (Slightly)
    10. CAS DataBase Reference: (S)-Propafenone(CAS DataBase Reference)
    11. NIST Chemistry Reference: (S)-Propafenone(107381-32-8)
    12. EPA Substance Registry System: (S)-Propafenone(107381-32-8)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 107381-32-8(Hazardous Substances Data)

107381-32-8 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 107381-32-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,7,3,8 and 1 respectively; the second part has 2 digits, 3 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 107381-32:
(8*1)+(7*0)+(6*7)+(5*3)+(4*8)+(3*1)+(2*3)+(1*2)=108
108 % 10 = 8
So 107381-32-8 is a valid CAS Registry Number.
InChI:InChI=1/C21H27NO3/c1-2-14-22-15-18(23)16-25-21-11-7-6-10-19(21)20(24)13-12-17-8-4-3-5-9-17/h3-11,18,22-23H,2,12-16H2,1H3/t18-/m0/s1

107381-32-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name (S)-Propafenone

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:107381-32-8 SDS

107381-32-8Relevant articles and documents

Colistin sulfate chiral stationary phase for the enantioselective separation of pharmaceuticals using organic polymer monolithic capillary chromatography ?

Fouad, Ali,Shaykoon, Montaser Sh.A.,Ibrahim, Samy M.,El-Adl, Sobhy M.,Ghanem, Ashraf

, (2019/03/19)

A new functionalized polymer monolithic capillary with a macrocyclic antibiotic, namely colistin sulfate, as chiral selector was prepared via the copolymerization of binary monomer mixtures consisting of glycidyl methacrylate (GMA) and ethylene glycol dimethacrylate (EGDMA) in porogenic solvents namely 1-propanol and 1,4-butanediol, in the presence of azobisiso-butyronitrile (AIBN) as initiator and colistin sulfate. The prepared capillaries were investigated for the enantioselective nano-LC separation of a group of racemic pharmaceuticals, namely, α- and β-blockers, anti-inflammatory drugs, antifungal drugs, norepinephrine-dopamine reuptake inhibitors, catecholamines, sedative hypnotics, antihistaminics, anticancer drugs, and antiarrhythmic drugs. Acceptable separation was achieved for many drugs using reversed phase chromatographic conditions with no separation achieved under normal phase conditions. Colistin sulfate appears to be useful addition to the available macrocyclic antibiotic chiral phases used in liquid chromatography.

Optimization of propafenone analogues as antimalarial leads

Lowes, David J.,Guiguemde, W. Armand,Connelly, Michele C.,Zhu, Fangyi,Sigal, Martina S.,Clark, Julie A.,Lemoff, Andrew S.,Derisi, Joseph L.,Wilson, Emily B.,Guy, R. Kiplin

supporting information; experimental part, p. 7477 - 7485 (2012/01/03)

Propafenone, a class Ic antiarrythmic drug, inhibits growth of cultured Plasmodium falciparum. While the drug's potency is significant, further development of propafenone as an antimalarial would require divorcing the antimalarial and cardiac activities as well as improving the pharmacokinetic profile of the drug. A small array of propafenone analogues was designed and synthesized to address the cardiac ion channel and PK liabilities. Testing of this array revealed potent inhibitors of the 3D7 (drug sensitive) and K1 (drug resistant) strains of P. falciparum that possessed significantly reduced ion channel effects and improved metabolic stability. Propafenone analogues are unusual among antimalarial leads in that they are more potent against the multidrug resistant K1 strain of P. falciparum compared to the 3D7 strain.

Therapeutic agents containing enantiomers of propafenone

-

, (2008/06/13)

Therapeutic agents containing enantiomers of propafenone, the preparation of the said agents and their use for certain groups of patients.

Optical Resolution of Propafenone and Diprafenone, Configuration of Propafenone Enantiomers

Blaschke, Gottfried,Walther, Bernd

, p. 561 - 564 (2007/10/02)

The chiral antiarrhythmic drugs propafenone (rac-1) and diprafenone (rac-3) were resolved by fractional crystallization of the diastereoisomeric salts with optically active di-O,O'-p-toluoyltartaric acid and tartaric acid, respectively.Derivatization with (+)-1-phenylethyl isocyanate and analytical separation of the diastereoisomers 2 and 4 by HPLC confirmed the optical purity of the enantiomers.CD spectra of (+)- and (-)-propafenone as copper complexes established the absolute configuration: (-)-1 is R-, (+)-1 S-configurated.

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