1073968-65-6 Usage
Uses
Used in Pharmaceutical Research:
5-Methoxy-1,2,3,4-tetrahydroquinoline hydrochloride is used as a research compound for studying the mechanisms of serotonin receptor activation. Its psychoactive effects make it valuable in exploring the potential therapeutic applications of serotonin receptor agonists in the treatment of various mental health disorders.
Used in Neuropharmacological Studies:
In the field of neuropharmacology, 5-MeO-THQ is utilized as a tool to investigate the role of serotonin receptors in modulating neural activity and behavior. This helps in understanding the underlying neurochemical processes associated with mood, perception, and cognition.
Used in Drug Development:
5-Methoxy-1,2,3,4-tetrahydroquinoline hydrochloride is employed in the development of novel therapeutic agents targeting serotonin receptors. Its agonistic properties guide the design of drugs with potential applications in treating mental health conditions, such as depression, anxiety, and other mood disorders.
Used in Toxicological Research:
In toxicology, 5-MeO-THQ serves as a reference substance to study the effects of psychoactive compounds on the central nervous system. This aids in assessing the safety and potential risks associated with the use of similar compounds in clinical settings.
Used in Forensic Analysis:
5-Methoxy-1,2,3,4-tetrahydroquinoline hydrochloride is utilized in forensic science for the detection and analysis of psychoactive substances in biological samples. This helps in identifying and quantifying the presence of such compounds in cases related to substance abuse or intoxication.
Check Digit Verification of cas no
The CAS Registry Mumber 1073968-65-6 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,7,3,9,6 and 8 respectively; the second part has 2 digits, 6 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1073968-65:
(9*1)+(8*0)+(7*7)+(6*3)+(5*9)+(4*6)+(3*8)+(2*6)+(1*5)=186
186 % 10 = 6
So 1073968-65-6 is a valid CAS Registry Number.
1073968-65-6Relevant articles and documents
Design and synthesis of a metabolically stable and potent antitussive agent, a novel δ opioid receptor antagonist, TRK-851
Sakami, Satoshi,Kawai, Koji,Maeda, Masayuki,Aoki, Takumi,Fujii, Hideaki,Ohno, Hiroshi,Ito, Tsuyoshi,Saitoh, Akiyoshi,Nakao, Kaoru,Izumimoto, Naoki,Matsuura, Hirotoshi,Endo, Takashi,Ueno, Shinya,Natsume, Kazuto,Nagase, Hiroshi
, p. 7956 - 7967 (2008/12/23)
We have previously reported on antitussive effect of (5R,9R,13S,14S)-17-cyclopropylmethyl-6,7-didehydro-4,5-epoxy-5′,6′-dihydro-3-methoxy-4′H-pyrrolo[3,2,1-ij]quinolino[2′,1′:6,7]morphinan-14-ol(1b) methanesulfonate (TRK-850), a selective δ opioid receptor antagonist which markedly reduced the number of coughs in a rat cough model. We designed TRK-850 based on naltrindole (NTI), a typical δ opioid receptor antagonist, to improve its permeability through the blood-brain barrier by introducing hydrophobic moieties to NTI. The ED50 values of NTI and compound 1b by intraperitoneal injections were 104 μg/kg and 2.07 μg/kg, respectively. This increased antitussive potency probably resulted from the improved brain exposure of compound 1b. However, 1b was extremely unstable toward metabolism by cytochrome P450. In this study, we designed and synthesized compound 1b derivatives to improve the metabolic instability, which resulted in affording highly potent and metabolically stable oral antitussive agent (5R,9R,13S,14S)-17-cyclopropylmethyl-6,7-didehydro-4,5-epoxy-8′-fluoro-5′,6′-dihydro-4′H-pyrrolo[3,2,1-ij]quinolino[2′,1′:6,7]morphinan-3,14-diol (1c) methanesulfonate (TRK-851).
