- 4-sulfenyl-2-carbamoyl-4-isoxazolin-3-ones: Biological isostere to 4- chloro-2-carbamoyl-4-isoxazolin-3-ones
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4-Sulfenyl-2-carbamoyl-4-isoxazolin-3-ones (4) were designed on the basis of biological isosterism and prepared in four steps. Some of these compounds showed sufficient pre-emergent herbicidal activities against various kinds of weeds. Among the synthesiz
- Kudo, Noriaki,Yoneda, Takamitsu,Sato, Kazuo,Honma, Toyokuni,Sugai, Soji
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p. 509 - 515
(2007/10/03)
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- Synthesis of 3-Hydroxyisoxazoles from β-Ketoesters and Hydroxylamine
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An efficient synthesis of 3-hydroxyisoxazoles from β-ketoesters and hydroxylamine was investigated.The reaction of the sodium salts of β-ketoesters and hydroxylamine at a low temperature, followed by quenching with an excess of conc.HCl under heating gave predominantly 3-hydroxyisoxazoles involving 4-sulfenylated 3-hydroxyisoxazoles.Starting from the prepared 4-(2,4-dichlorobenzyl)-3-hydroxy-5-methylisoxazole, a potential herbicidal compound, 4-(2,4-dichlorobenzoyl)-3-hydroxy-5-methylisoxazole, was also synthesized in five steps.
- Sato, Kazuo,Sugai, Soji,Tomita, Kazuo
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p. 1831 - 1838
(2007/10/02)
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