Design, Synthesis and Evaluation of a Series of 1,5-Diaryl-1,2,3-triazole-4-carbohydrazones as Inhibitors of the YAP-TAZ/TEAD Complex
Starting from our previously reported hit, a series of 1,5-diaryl-1,2,3-triazole-4-carbohydrazones were synthesized and evaluated as inhibitors of the YAP/TAZ-TEAD complex. Their binding to hTEAD2 was confirmed by nanodifferential scanning fluorimetry, an
STEREOSELECTIVE PREPARATION OF METHYL (Z)-CINNAMATES BY FAVORSKII REARRANGEMENT
1,3-Dibromo-1-phenylacetones, readily prepared by direct bromination of the parent phenylacetone, react with methanolic sodium methoxide to yield stereoselectively methyl (Z) cinnamates in good yield.
Engler, Thomas A.,Falter, Wolfgang
p. 4119 - 4120
(2007/10/02)
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