107544-70-7

Basic information

• Product Name: (2-Brom-phenyl)-benzyl-thioharnstoff
• Synonyms: (2-Brom-phenyl)-benzyl-thioharnstoff
• CAS NO: 107544-70-7
• Molecular Weight: 321.241
• Mol File: 107544-70-7.mol

Chemical Properties

• CAS DataBase Reference: (2-Brom-phenyl)-benzyl-thioharnstoff(CAS DataBase Reference)
• NIST Chemistry Reference: (2-Brom-phenyl)-benzyl-thioharnstoff(107544-70-7)
• EPA Substance Registry System: (2-Brom-phenyl)-benzyl-thioharnstoff(107544-70-7)

Safety Data

• Hazardous Substances Data: 107544-70-7(Hazardous Substances Data)

Upstream product

• 3959-05-5 2-bromobenzylamine 
• 622-78-6 Benzyl isothiocyanate 
• 13037-60-0 1-bromo-2-isothiocyanatobenzene 
• 100-46-9 benzylamine 

Downstream Products

• 1195791-24-2 C₁₈H₂₀BrN₃O 
• 1195791-22-0 C₁₈H₂₀BrN₃ 
• 21816-82-0 N-benzyl-2-aminobenzo[d]thiazole 

Relevant articles and documents

Gram Scalable Method to Synthesize Biscarbodiimides and Asymmetric Monocarbodiimides: A Platform to Access an Array of Phosphaguanidines, Amidines, and Guanidines

A mild, broadly functional group tolerant methodology has been developed to access a variety of mono- and bis-carbodiimides in good yield and high purity on multigram scale. Direct addition into these versatile motifs facilitated the rapid synthesis of a library of novel amidinines, guanidines, and phosphaguandines.

Metal-free synthesis of 2-substituted (N, O, C) Benzothiazoles via an intramolecular C-S bond formation

An efficient, economical, and convenient method was developed for the preparation of 2-substituted (N, O, C) benzothiazoles from N′-substituted- N-(2-halophenyl)thioureas, O′-substituted-N-(2-halophenyl) carbamothioates, or N-(2-halophenyl) thioamides via a base-promoted cyclization in dioxane without any transition metal. A one-pot variant combining the synthesis of the thiourea and the cyclization was also demonstrated. High yields were obtained, and a variety of functional groups were tolerated under these conditions. Transition-metal-free, mild reactive conditions, wide application scope, and shorter reaction times make this method superior to the reported methods for the synthesis of 2-substituted benzothiazoles and suitable for combinatorial format.

Copper- and palladium-catalyzed intramolecular C-S bond formation: A convenient synthesis of 2-aminobenzothiazoles

Copper- and palladium-catalyzed intramolecular C-S bond formation by cross-coupling between an aryl halide and thiourea functionality is demonstrated for the synthesis of 2-aminobenzothiazoles, wherein the Cu-catalyzed protocol is generally superior and more cost effective than the Pd-catalyzed protocol; the Cu-catalyzed reaction also further expands recent studies exploring the utility of Cu salts as replacements for Pd in carbon-heteroatom bond-forming reactions. A one-pot variant combining the synthesis of the thiourea and the cyclization was also demonstrated.