- An efficient 3-acylquinoline synthesis from acetophenones and anthranil: Via C(sp3)-H bond activation mediated by Selectfluor
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An efficient method for the synthesis of 3-functionalized quinolines from commercially available acetophenones and anthranil has been described. Selectfluor propels the C(sp3)-H bond activation of the acetophenones and aza-Michael addition of anthranil resulting in annulated 3-acylquinolines in moderate to high yields. DMSO acts not only as a solvent but also as a one carbon donor in the reaction.
- Gao, Yejun,Hider, Robert C.,Ma, Yongmin
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p. 10340 - 10344
(2019/04/10)
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- Transition-Metal-Free Quinoline Synthesis from Acetophenones and Anthranils via Sequential One-Carbon Homologation/Conjugate Addition/Annulation Cascade
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A transition-metal-free method for the construction of functionalized quinolines from readily available acetophenones and anthranils is reported. This one-pot reaction cascade involves in situ generation of α,β-unsaturated ketones from the acetophenone via one-carbon homologation by DMSO followed by the aza-Michael addition of anthranils and subsequent annulation. DMSO acted in this reaction not only as solvent but also as one carbon source, thus providing a highly atom-economical and environmentally benign approach for the synthesis of 3-substituted quinolines.
- Wakade, Sandip Balasaheb,Tiwari, Dipak Kumar,Ganesh, Pothapragada S. K. Prabhakar,Phanindrudu, Mandalaparthi,Likhar, Pravin R.,Tiwari, Dharmendra Kumar
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supporting information
p. 4948 - 4951
(2017/09/23)
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- Synthesizing method of aromatic pyridinopyridine compound
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The invention discloses a synthesizing method of an aromatic pyridinopyridine compound, and belongs to the technical field of organic synthesizing. According to the technical scheme, the characteristics of the synthesizing method refers to the description. The method is simple, efficient, convenient to operate, mild in conditions, and wide in substrate applying scope.
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Paragraph 0084; 0085; 0086
(2017/07/20)
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- α,β-Functionalization of saturated ketones with anthranils: Via Cu-catalyzed sequential dehydrogenation/aza-Michael addition/annulation cascade reactions in one-pot
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An efficient method to access functionalized quinolines from the readily available saturated ketones and anthranils has been explored. This one-pot cascade reaction involves the in situ generation of α,β-unsaturated ketones by the copper catalysed dehydro
- Tiweri, Dipak Kumar,Phanindrudu, Mandalaparthi,Wakade, Sandip Balasaheb,Nanubolu, Jagadeesh Babu,Tiwari, Dharmendra Kumar
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supporting information
p. 5302 - 5305
(2017/07/10)
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- Reaction of α-oxoketene-N,S-arylaminoacetals with Vilsmeier reagents: An efficient route to highly functionalized quinolines and their benzo/hetero-fused analogues
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A simple, highly efficient, and regioselective synthesis of functionalized quinolines through Vilsmeier cyclization of a variety of α-oxoketene-N,S-anilinoacetals has been reported. The cyclization is found to be facile with N,S-acetals bearing strongly a
- Mahata,Venkatesh,Syam Kumar,Ila,Junjappa
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p. 3966 - 3975
(2007/10/03)
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