107638-86-8Relevant articles and documents
Highly enantioselective Michael addition of cyclic 1,3-dicarbonyl compounds to α,β-unsaturated ketones
Xie, Jian-Wu,Yue, Lei,Chen, Wei,Du, Wei,Zhu, Jin,Deng, Jin-Gen,Chen, Ying-Chun
, p. 413 - 415 (2007)
The highly enantioselective Michael addition of 1,3-cyclic dicarbonyl compounds to α,β-unsaturated ketones was reported to be catalyzed by an organic primary amine derived from quinine. A chiral anticoagulant drug, (S)-warfarin, was directly prepared in 96% ee, and other related important adducts were also obtained in excellent enantioselectivity (89-99% ee).
First aromatic amine organocatalysed activation of α,β-unsaturated ketones
Sonsona, Isaac G.,Marqués-López, Eugenia,Gimeno, M. Concepción,Herrera, Raquel P.
, p. 12233 - 12240 (2019/08/12)
This work provides an unprecedented example of a chiral aromatic amine used to activate α,β-unsaturated ketones in asymmetric aminocatalysis. Chiral aromatic diamine VII has been efficiently employed, as a proof of concept, in the Michael addition reaction between benzylideneacetones (1a-f) and coumarins (2a-d). The reaction gives rise to warfarin derivatives 3 with promising results using this family of catalysts for the first time. The additional studies performed supported the bifunctional mode of activation of the chiral catalyst VII and the covalent nature of the interactions between the catalyst VII and benzylideneacetones 1.
