- Green synthesis of halogenated thiophenes, selenophenes and benzo[b]selenophenes using sodium halides as a source of electrophilic halogens
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Herein, we report the first synthesis of chlorinated benzo[b]selenophenes via environmentally friendly electrophilic chlorocyclization reaction using “table salt” as a source of “electrophilic chlorine” and ethanol as a solvent. In addition, the synthesis
- Kesharwani, Tanay,Giraudy, Krystal A.,Morgan, Jordan L.,Kornman, Cory,Olaitan, Abayomi D.
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p. 638 - 641
(2017/01/25)
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- Copper(II)-mediated intramolecular cyclization of (Z)-chalcogenoenynes: Synthesis of 3-halochalcogenophene derivatives
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We present our results on the cyclization of (Z)-chalcogenoenynes mediated by copper(II) salts to afford 3-halochalcogenophenes in satisfactory yields through an intramolecular 5-endo-dig cyclization. The methodology was carried out using CuCl2
- Barancelli, Daniela A.,Schumacher, Ricardo F.,Leite, Marlon R.,Zeni, Gilson
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experimental part
p. 6713 - 6718
(2012/01/04)
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- COPPER-CATALYZED C-H BOND ARYLATION
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The present invention is a one-step method for efficiently converting carbon-hydrogen bonds into carbon-carbon bonds using a combination of aryl halides, a substrate, and a copper salt as catalyst. This method allows faster introduction of complex molecular entities, a process that would otherwise require many more steps. This invention is particularly relevant for the organic synthesis of complex molecules such as, but not limited to, pharmacophores and explosives.
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Page/Page column 22
(2009/04/24)
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- A general method for copper-catalyzed arylation of arene C-H bonds
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A general method for copper-catalyzed arylation of sp2 C-H bonds with pKa's below 35 has been developed. The method employs aryl halide as the coupling partner, lithium alkoxide or K3PO4 base, and DMF, DMPU, or mixed DMF/xylenes solvent. A variety of electron-rich and electron-poor heterocycles such as azoles, caffeine, thiophenes, benzofuran, pyridine oxides, pyridazine, and pyrimidine can be arylated. Furthermore, electron-poor arenes possessing at least two electron-withdrawing groups on a benzene ring can also be arylated. Two arylcopper-phenanthroline complex intermediates were independently synthesized.
- Do, Hien-Quang,Khan, Rana M. Kashif,Daugulis, Olafs
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supporting information; experimental part
p. 15185 - 15192
(2009/03/12)
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