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107842-57-9

5-Amino-1-(3-chlorophenyl)-3-methyl-1H-pyrazole-4-carbonitrile is an organic compound with the molecular formula C11H8ClN5. It is a derivative of the pyrazole family, characterized by the presence of a chlorine atom attached to the phenyl ring and a nitrile group. 5-Amino-1-(3-chlorophenyl)-3-methyl-1H-pyrazole-4-carbonitrile is known for its potential applications in various fields due to its unique chemical structure and properties.

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  • 107842-57-9 Structure

  • Basic information

    1. Product Name: 5-Amino-1-(3-chlorophenyl)-3-methyl-1H-pyrazole-4-carbonitrile
    2. Synonyms: 5-Amino-1-(3-chlorophenyl)-3-methyl-1H-pyrazole-4-carbonitrile;5-Amino-4-cyano-1-(3-chlorophenyl)-3-methylpyrazole
    3. CAS NO:107842-57-9
    4. Molecular Formula: C10H6ClN4R
    5. Molecular Weight: 217.63
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 107842-57-9.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: 2-8°C
    8. Solubility: N/A
    9. CAS DataBase Reference: 5-Amino-1-(3-chlorophenyl)-3-methyl-1H-pyrazole-4-carbonitrile(CAS DataBase Reference)
    10. NIST Chemistry Reference: 5-Amino-1-(3-chlorophenyl)-3-methyl-1H-pyrazole-4-carbonitrile(107842-57-9)
    11. EPA Substance Registry System: 5-Amino-1-(3-chlorophenyl)-3-methyl-1H-pyrazole-4-carbonitrile(107842-57-9)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 107842-57-9(Hazardous Substances Data)

107842-57-9 Usage

Uses

Used in Pharmaceutical Industry:
5-Amino-1-(3-chlorophenyl)-3-methyl-1H-pyrazole-4-carbonitrile is used as a precursor in the synthesis of tetrazole compounds for the treatment of Leishmania. Leishmania is a parasitic disease that affects various parts of the body, including the skin, mucosal surfaces, and internal organs. The compound plays a crucial role in the development of new drugs to combat this disease by providing a structural foundation for the creation of more effective and targeted therapeutic agents.

Check Digit Verification of cas no

The CAS Registry Mumber 107842-57-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,7,8,4 and 2 respectively; the second part has 2 digits, 5 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 107842-57:
(8*1)+(7*0)+(6*7)+(5*8)+(4*4)+(3*2)+(2*5)+(1*7)=129
129 % 10 = 9
So 107842-57-9 is a valid CAS Registry Number.

107842-57-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name 5-Amino-1-(3-chlorophenyl)-3-methyl-1H-pyrazole-4-carbonitrile

1.2 Other means of identification

Product number -
Other names 5-amino-1-(3-chlorophenyl)-3-methylpyrazole-4-carbonitrile

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:107842-57-9 SDS

107842-57-9Downstream Products

107842-57-9Relevant articles and documents

Synthesis and activity of novel tetrazole compounds and their pyrazole-4-carbonitrile precursors against Leishmania spp

Faria, Jéssica V.,Dos Santos, Maurício S.,Bernardino, Alice M.R.,Becker, Klaus M.,Machado, Gérzia M.C.,Rodrigues, Raquel F.,Canto-Cavalheiro, Marilene M.,Leon, Leonor L.

supporting information, p. 6310 - 6312 (2013/11/19)

A new series of 5-(1-aryl-3-methyl-1H-pyrazol-4-yl)-1H-tetrazole derivatives (4a-m) and their precursor 1-aryl-3-methyl-1H-pyrazole-4- carbonitriles (3a-m) were synthesized and evaluated as antileishmanials against Leishmania braziliensis and Leishmania amazonensis promastigotes in vitro. In parallel, the cytotoxicity of these compounds was evaluated on the RAW 264.7 cell line. The results showed that among the assayed compounds the substituted 3-chlorophenyl (4a) (IC50/24 h = 15 ± 0.14 μM) and 3,4-dichlorophenyl tetrazoles (4d) (IC50/24 h = 26 ± 0.09 μM) were the most potent against L. braziliensis promastigotes, as compared the reference drug pentamidine, which presented IC50 = 13 ± 0.04 μM. In addition, 4a and 4d derivatives were less cytotoxic than pentamidine. However, these tetrazole derivatives (4) and pyrazole-4- carbonitriles precursors (3) differ against each of the tested species and were more effective against L.braziliensis than on L. amazonensis.

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