- ANTI-GLYCATED CD59 ANTIBODIES AND USES THEREOF
-
This invention includes, in part, methods of preparing glycated polypeptide antigens and antibodies that specifically recognize glycated epitopes on polypeptides. The invention also relates, in part, to the preparation and use of antibodies that specifically recognize and bind with high affinity to glycated epitopes on glycated CD59 polypeptides, including, but not limited to a K41-glycated epitope on CD59. In some aspects, the invention also includes, hybridoma cell lines that produce antibodies that specifically bind glycated CD59; antibodies and antigen-binding fragments thereof produced with the methods of the invention; and methods of using the antibodies and antigen-binding fragments thereof for diagnosis and treatment of diseases and conditions such as abnormal glycemic control, pre-diabetes, diabetes, and diabetes-associated conditions.
- -
-
Page/Page column 64-65
(2009/01/20)
-