- Factor xa inhibitors with aryl-amidines and derivatives, and prodrugs thereof
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The present invention relates to a compound with aryl-amidines, particularly amidinoaryl-cyclopropanes, amidinoarylmethyl-pyrroles, amidinoaryl-benzenes, amidinoaryl-pyridines, or amindonoaryl-alanines, represented by formula (1), a pharmaceutically acceptable salt, a prodrug, a hydrate, a solvate or an isomer thereof, which are inhibitors of coagulation enzyme, factor Xa (FXa). The present invention also relates to a pharmaceutical composition containing the compound, and a method of using the same as an anticoagulant agent for treatment and prevention of thrombosis disorders.
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- Benzyne formation and the stepwise decomposition of benzenediazonium-2-carboxylate: A re-investigation
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A study of the decomposition reactions of benzenediazonium-2-carboxylate, carried out in a number of mixed nucleophilic solvents, shows that a number of mechanistic pathways can operate simultaneously and can afford, in addition to products derived from benzyne, products derived from the 2-carboxyphenyl cation and the 2-carboxyphenyl radical: benzyne formation is favoured in halogenated solvents and occurs by the concerted loss of nitrogen and carbon dioxide.
- Christopher Buxton,Fensome, Mark,Heaney, Harry,Mason, Kenneth G.
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p. 2959 - 2968
(2007/10/02)
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