- Rh(I)-catalyzed direct arylation of azines
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The Rh(I)-catalyzed direct arylation of azines has been developed. Quinolines and 2-substituted pyridines couple with aryl bromides to efficiently afford ortho-arylated azine products using the commercially available and air-stable catalyst [RhCl(CO)2]2. Electron-deficient and electron-rich aromatic bromides couple in good yields, and hydroxyl, chloro, fluoro, trifluoromethyl, ether, and ketone functionalities are compatible with the reaction conditions. Aroyl chlorides also serve as effective azine coupling partners to give ortho-arylation products via a decarbonylation pathway.
- Berman, Ashley M.,Bergman, Robert G.,Ellman, Jonathan A.
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supporting information; experimental part
p. 7863 - 7868
(2011/02/21)
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- Rh(I)-catalyzed direct arylation of pyridines and quinolines
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A Rh(I)-catalyzed direct arylation of pyridine and quinoline heterocycles has been developed. The method provides rapid entry into an important class of substituted heterocycles employing inexpensive and readily available starting materials. Copyright
- Berman, Ashley M.,Lewis, Jared C.,Bergman, Robert G.,Ellman, Jonathan A.
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supporting information; experimental part
p. 14926 - 14927
(2009/03/12)
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