- Concise total synthesis of aplysinellamides A and B
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Concise and efficient total syntheses of bromotyrosine-derived metabolites aplysinellamides A and B, isolated from Australian marine sponge Aplysinella sp., have been accomplished in seven steps. A condensation between cinnamic acid and Boc-D-lysine methyl ester was applied to form the amide skeleton as a key step.
- Gan, Haifeng,Huang, Yu,Feng, Weiyang,Zhu, Wentong,Guo, Kai
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Read Online
- ANTI-HIV COMPOUNDS
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This invention provides, among other things, tetrahydroisoquinolines useful for treating viral infections, pharmaceutical formulations containing such compounds, as well as methods of inhibiting the replication of a virus, such as HIV, or treating a disease, such as AIDS.
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Paragraph 0356
(2016/07/05)
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- SULPHONYLAMINOPYRROLIDINONE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
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The invention relates to new sulphonylaminopyrrolidinone compounds having antithrombotic activity which, in particular, inhibit blood clotting factor IXa and/ or factor Xa, to processes for their preparation and to use thereof as drugs.
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Page/Page column 48
(2013/07/05)
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- The first total synthesis of aplysamine 6, an inhibitor of isoprenylcysteine carboxy methyltransferase
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The first total synthesis of aplysamine 6, an inhibitor of isoprenylcysteine carboxy methyltransferase (Icmt), was accomplished in an overall high yielding reaction sequence.
- Ullah, Nisar,Arafeh, Khaled M.
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scheme or table
p. 158 - 160
(2009/04/14)
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- NOVEL BICYCLIC AROMATIC COMPOUNDS, THE PRODUCTION AND USE THEREOF IN THE FORM OF DRUGS
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The invention relates to novel aromatic bicycle compounds of formula (I), wherein Ar, X, Y and R1-R3 are such as specified in a claim 1. Said invention also relates to the tautomers, enantiomers, diasteriomers, mixtures, pro-drugs an
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