cas 1086-02-8, PYRIDINITRIL | Articles data ｜lookchem

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1086-02-8

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Synthesis and biological evaluation of 3,6-diamino-1H-pyrazolo[3,4-b]pyridine derivatives as protein kinase inhibitors
The synthesis and biological evaluation of a number of differently substituted 3,6-diamino-1H-pyrazolo[3,4-b]pyridine derivatives are reported. From the inhibition results on a selection of disease-relevant protein kinases [IC50 (μM) DYRK1A = 11; CDK5 = 0.41; GSK-3 = 1.5] we have observed that 3,6-diamino-4-phenyl-1H-pyrazolo[3,4-b]pyridine-5-carbonitrile (4) constitutes a potential new and simple lead compound in the search of drugs for the treatment of Alzheimer's disease.
Chioua, Mourad,Samadi, Abdelouahid,Soriano, Elena,Lozach, Olivier,Meijer, Laurent,Marco-Contelles, Jose
supporting information; scheme or table
p. 4566 - 4569
(2010/04/24)

A Synthesis of Heterocyclic Ring Systems. Pyridothienopyrrolizine and Pyridodithienodipyrrolizine
A synthesis for two new polycyclic heterocyclic ring systems is reported.Cyclization of pyrrolidinocarboxamide derivatives of ethyl 3-(pyrrol-1-yl)thienopyridine-2-carboxylate (4) and ethyl 3,5-di(pyrrol-1-yl)dithienopyridine-2,6-dicarboxylate (11) afford iminium salts that were transformed into the new heteropolycyclic compounds (6) and (13), respectively.
Peinador, Carlos,Veiga, M. Carmen,Vilar, Juan,Quintela, Jose M.
p. 1299 - 1306
(2007/10/02)

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Chemical Properties

Melting Point: 203-204 °C
Boiling Point: 447.3 °C at 760 mmHg
Flash Point:224.3 °C
Density: 1.48 g/cm³
Vapor Pressure: 3.4E-08mmHg at 25°C
Refractive Index: 1.657
PKA: -8.78±0.10(Predicted)
PSA: 60.47000
LogP: 3.79876

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