- Discovery of 3,3′-Spiro[Azetidine]-2-oxo-indoline Derivatives as Fusion Inhibitors for Treatment of RSV Infection
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A new series of 3,3′-spirocyclic-2-oxo-indoline derivatives was synthesized and evaluated against respiratory syncytial virus (RSV) in a cell-based assay and animal model. Extensive structure-activity relationship study led to a lead compound 14h, which e
- Shi, Weihua,Jiang, Zhigan,He, Haiying,Xiao, Fubiao,Lin, Fusen,Sun, Ya,Hou, Lijuan,Shen, Liang,Han, Lixia,Zeng, Minggao,Lai, Kunmin,Gu, Zhengxian,Chen, Xinsheng,Zhao, Tao,Guo, Li,Yang, Chun,Li, Jian,Chen, Shuhui
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supporting information
p. 94 - 97
(2018/02/19)
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- RSV ANTIVIRAL COMPOUNDS
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Inhibitors of RSV replication of formula RI including stereochemically isomeric forms, and salts or solvates thereof, wherein R22, W, Q, V, Z p,s,and Het have the meaning as defined herein. The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use, alone or in combination with other RSV inhibitors, in RSV therapy.
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Page/Page column 36
(2014/05/07)
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- TRICYCLIC SPIROCYCLE DERIVATIVES AND METHODS OF USE
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The present invention relates to novel Tricyclic Spirocycle Derivatives, pharmaceutical compositions comprising the Tricyclic Spirocycle Derivatives and the use of these compounds for treating or preventing allergy, an allergy-induced airway response, congestion, a cardiovascular disease, an inflammatory disease, a gastrointestinal disorder, a neurological disorder, a metabolic disorder, obesity or an obesity-related disorder, diabetes, a diabetic complication, impaired glucose tolerance or aired fasting glucose.
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Page/Page column 28-29
(2011/07/29)
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- NOVEL SPIROOXYINDOLE COMPOUNDS AND DRUGS CONTAINING SAME
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A Spiro oxindole compound represented by formula (1) of the present invention or salt thereof, or their solvate shows a superior inhibitory effect of 11β-hydroxysteroid dehydrogenasel, and is useful as an agent for preventing or treating a disease that involves 11β-hydroxysteroid dehydrogenasel (in particular, diabetes, insulin resistance, diabetes complication, obesity, dyslipidemia, hypertension, fatty liver, or metabolic syndrome).
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Page/Page column 12
(2009/01/20)
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