108664-39-7

Basic information

• Product Name: 1-biphenyl-4-yl-2-(1H-1,2,4-triazol-1-ylmethyl)prop-2-en-1-one
• Synonyms: 1-(biphenyl-4-yl)-2-(1H-1,2,4-triazol-1-ylmethyl)prop-2-en-1-one; 2-Propen-1-one, 1-(1,1'-biphenyl)-4-yl-2-(1H-1,2,4-triazol-1-ylmethyl)-; 2-propen-1-one, 1-[1,1'-biphenyl]-4-yl-2-(1H-1,2,4-triazol-1-ylmethyl)-
• CAS NO: 108664-39-7
• Molecular Formula: C₁₈H₁₅N₃O
• Molecular Weight: 289.3312
• Mol File: 108664-39-7.mol

Chemical Properties

• Boiling Point: 510.2°C at 760 mmHg
• Flash Point: 262.3°C
• Density: 1.14g/cm³
• Vapor Pressure: 1.59E-10mmHg at 25°C
• Refractive Index: 1.616
• CAS DataBase Reference: 1-biphenyl-4-yl-2-(1H-1,2,4-triazol-1-ylmethyl)prop-2-en-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-biphenyl-4-yl-2-(1H-1,2,4-triazol-1-ylmethyl)prop-2-en-1-one(108664-39-7)
• EPA Substance Registry System: 1-biphenyl-4-yl-2-(1H-1,2,4-triazol-1-ylmethyl)prop-2-en-1-one(108664-39-7)

Safety Data

• Hazardous Substances Data: 108664-39-7(Hazardous Substances Data)

Usage

Chemical structure

1-biphenyl-4-yl-2-(1H-1,2,4-triazol-1-ylmethyl)prop-2-en-1-one is an organic compound with a complex chemical structure, consisting of a biphenyl group attached to a propenone group through a 1,2,4-triazole ring.

Application in medicinal chemistry

It is commonly used in medicinal chemistry as a building block for the synthesis of various pharmaceuticals and bioactive molecules.

Potential antifungal and antimicrobial properties

The compound has been studied for its potential antifungal and antimicrobial properties.

Bioactivity of the triazole moiety

The triazole moiety in its structure is known for its bioactivity.

Structural diversity provided by the biphenyl group

The biphenyl group provides additional structural diversity for the design of novel drugs.

Versatility

1-biphenyl-4-yl-2-(1H-1,2,4-triazol-1-ylmethyl)prop-2-en-1-one is a versatile chemical.

Potential applications

It has potential applications in drug discovery and development.

Upstream product

• 5409-63-2 1-(4-biphenyl-1-yl)-3-dimethylamino-1-propanone hydrochloride 
• 92-91-1 biphenyl-4-acetaldehyde 

Relevant articles and documents

Synthesis and Antifungal Activity of a Series of Novel 1,2-Disubstituted Propenones

To find an antifungal agent other than those of the imidazole and triazole series, a new class of 1,2-disubstituted propenones I and II was prepared and tested for antifungal activity.Comparison of the structure-activity relationships showed that the conjugated structure of carbonyl and exomethylene groups in I and II plays an important role in potent antifungal acivity.However, it is noteworthy that compounds 53, 54, and 56, which have a hydroxymethyl or methoxymethyl group instead of an exo-methylene group in I, also showed potent activity.Although many compounds exhibited strong antifungal activity in vitro, none showed activity in vivo of oral efficacy against subacute systemic candidiasis in mice. '