A facile protocol for the preparation of 5-alkylidene and 5-imino substituted hydantoins from N,N′-disubstituted parabanic acids
A convenient procedure for the preparation of various substituted (thio)hydantoins is described. The method is based on Wittig and aza-Wittig reactions of parabanic acids with phosphonium ylides. The reactions occurred both regio- and stereo-selectively.
üng?ren, ?evket Hakan,Kani, Ibrahim,Günay, Ahmet
supporting information; experimental part
p. 4758 - 4762
(2012/09/07)
A facile synthesis of N-carbamoylamino acids
N-Carbamoylamino acids were obtained through the alkylation of monosubstituted parabanic acids followed by hydrolysis of the intermediate products. This new methodology furnishes structurally and functionally diverse N-carbamoylamino acids in high preparative yields and excellent purity. Georg Thieme Verlag Stuttgart.
Bogolubsky, Andrey V.,Ryabukhin, Sergey V.,Pakhomov, Gennadiy G.,Ostapchuk, Eugeniy N.,Shivanyuk, Alexander N.,Tolmachev, Andrey A.
experimental part
p. 2279 - 2282
(2009/05/30)
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