108683-62-1

Basic information

• Product Name: 2-(Chloromethyl) benzaldehyde
• Synonyms: 2-(Chloromethyl) benzaldehyde
• CAS NO: 108683-62-1
• Molecular Formula: C₈H₇ClO
• Molecular Weight: 154.59358
• Mol File: 108683-62-1.mol

Chemical Properties

• Boiling Point: 252.0±15.0 °C(Predicted)
• Appearance: /
• Density: 1.200±0.06 g/cm3(Predicted)
• Storage Temp.: Refrigerator, under inert atmosphere
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• CAS DataBase Reference: 2-(Chloromethyl) benzaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(Chloromethyl) benzaldehyde(108683-62-1)
• EPA Substance Registry System: 2-(Chloromethyl) benzaldehyde(108683-62-1)

Safety Data

• Hazardous Substances Data: 108683-62-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-(Chloromethyl) benzaldehyde is used as a key reagent for the preparation of 2-formylbenzylphosphoric acid derivatives, which are essential in the treatment of diseases caused by viruses. Its role in the synthesis of these derivatives is crucial for developing antiviral medications.
Used in Chemical Synthesis:
In the field of chemical synthesis, 2-(Chloromethyl) benzaldehyde serves as a reagent for the preparation of isochromanones. This is achieved through N-heterocyclic carbene-catalyzed annulation of in-situ generated o-quinodimethanes with ketones. Isochromanones are important intermediates in the synthesis of various organic compounds and pharmaceuticals.

Upstream product

• 142066-41-9 2-(chloromethyl)-phenyl methanol 
• 30293-58-4 α,α,α'-trichloro-o-xylene 
• 612-13-5 2-cyanobenzyl chloride 

Downstream Products

• 135795-73-2 diethyl 2-formylbenzylphosphonate 
• 1086328-92-8 2-(2,5-dimethylphenoxymethyl)benzaldehyde 
• 87-41-2 2-benzofuran-1(3H)-one 
• 153396-48-6 3-phenyl-1-isochromanol 
• 153396-48-6 3-phenylisochroman-1-ol 
• 100733-88-8 2-(β-Phenylethyl)-2H-isoindol 

Relevant articles and documents

Stereoselective synthesis of 1,2,2-trisubstituted indane derivatives using a tandem SN2-michael addition sequence

An efficient strategy is developed for the synthesis of 1,2,2-trisubstituted indane derivatives employing a tandem SN2- Michael reaction sequence. The method is extended towards the synthesis of spiroindanes and indanopiperidines. Georg Thieme Verlag Stuttgart.

Annulation of o-Quinodimethanes through N-Heterocyclic Carbene Catalysis for the Synthesis of 1-Isochromanones

The activation of 2-(bromomethyl)benzaldehydes using N-heterocyclic carbenes represents a novel approach to the generation of o-quinodimethane (o-QDM) intermediates. Coupling with ketones such as phenylglyoxylates, isatins, or trifluoromethyl ketones via [4 + 2] annulation gives access to functionalized 1-isochromanones.

METHOD FOR PRODUCING 2-CHLOROMETHYLBENZALDEHYDE, 2-CHLOROMETHYLBENZALDEHYDE-CONTAINING COMPOSITION, AND METHOD FOR STORING SAME

A process for obtaining an industrially useful 2-chloromethylbenzaldehyde-containing liquid composition at a high yield is provided. More specifically, a process for producing 2-chloromethylbenzaldehyde comprising step (A) of mixing 1-dichloromethyl-2-chloromethylbenzene and sulfuric acid having a concentration of 84.5% by weight or more; and step (B) of mixing a mixture obtained in step (A) and water is provided.