Methotrexate Analogues. 30. Dihydrofolate Reductase Inhibition and in Vitro Tumor Cell Growth Inhibition by Nε-(Haloacetyl)-L-lysine and Nδ-(Haloacetyl)-L-ornithine Analogues and an Acivicin Analogue of Methotrexate
Analogues of methotrexate (MTX) with strong alkylating activity were prepared by replacing the L-glutamate side chain with Nω-haloacetyl derivatives of L-lysine and L-ornithine.Haloacetylation was accomplished in 30-40percent yield by reaction
Rosowsky, Andre,Solan, Vishnu C.,Forsch, Ronald A.,Delcamp, Tavner J.,Baccanari, David P.,Freisheim, James H.
p. 1463 - 1469
(2007/10/02)
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