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1088434-86-9

ACS 67 is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 1088434-86-9 Structure

  • Basic information

    1. Product Name: ACS 67
    2. Synonyms: ACS 67;ACS 67 Exclusive;JEEWZRQQYWVJCX-WEWVERJPSA-N
    3. CAS NO:1088434-86-9
    4. Molecular Formula: C32H38O5S3
    5. Molecular Weight: 598.83612
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1088434-86-9.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: ≤2mg/ml in ethanol;20mg/ml in DMSO;30mg/ml in dimethyl formamide
    9. CAS DataBase Reference: ACS 67(CAS DataBase Reference)
    10. NIST Chemistry Reference: ACS 67(1088434-86-9)
    11. EPA Substance Registry System: ACS 67(1088434-86-9)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1088434-86-9(Hazardous Substances Data)

1088434-86-9 Usage

Biological Activity

acs 67 is an analog of latanoprost acid.latanoprost, an f-series prostaglandin (pg) analog, has been approved for use as an ocular hypotensive drug for the treatment of glaucoma clinically. latanoprost is an isopropyl ester, a prodrug form which is converted to free latanoprost acid by endogenous esterase enzymes.

in vitro

in previous study, acs 67 was found to be able to increase the reduced glutathione levels in normotensive pigmented rabbits significantly after single administration in a dose-dependent manner. furthermore, in glaucomatous pigmented rabbits after repeated 5-day administration, acs 67 could also increase the gsh levels when compared with latanoprost. in addition, it was found that acs 67 could significantly increase the cgmp levels in glaucomatous pigmented rabbits and these data with the combination supported that the increase of cgmp was due to the sulfurated moiety of acs 67. moreover, the tolerability was measured in new zealand albino rabbits at three different concentrations of acs 67, and results indicated that acs 67 was very well tolerated in draize test [1].

references

[1] e. perrino, c. uliva, c. lanzi, et al. new prostaglandin derivative for glaucoma treatment. bioorganic & medicinal chemistry letters 19, 1639-1642 (2009).

Check Digit Verification of cas no

The CAS Registry Mumber 1088434-86-9 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,8,8,4,3 and 4 respectively; the second part has 2 digits, 8 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1088434-86:
(9*1)+(8*0)+(7*8)+(6*8)+(5*4)+(4*3)+(3*4)+(2*8)+(1*6)=179
179 % 10 = 9
So 1088434-86-9 is a valid CAS Registry Number.

1088434-86-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name ACS 67

1.2 Other means of identification

Product number -
Other names 5-p-nitrobenzylidene-2-thiohydantoin

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1088434-86-9 SDS

1088434-86-9Downstream Products

1088434-86-9Relevant articles and documents

New prostaglandin derivative for glaucoma treatment

Perrino, Elena,Uliva, Caterina,Lanzi, Cecilia,Soldato, Piero Del,Masini, Emanuela,Sparatore, Anna

, p. 1639 - 1642 (2009)

A hydrogen sulphide-releasing derivative of latanoprost acid (ACS 67) was synthesized and tested in vivo to evaluate its activity on reduction of intraocular pressure and tolerability. Glutathione (GSH) and cGMP content were also measured in the aqueous h

PROSTAGLANDIN PHARMACEUTICAL COMPOSITIONS

-

Page/Page column 4, (2010/07/08)

The present invention relates to new prostaglandin derivatives having improved pharmacological activity and enhanced tolerability. They can be employed for the treatment of glaucoma and ocular hypertension.

PROSTAGLANDIN PHARMACEUTICAL COMPOSITIONS

-

, (2009/01/20)

The present invention relates to new prostaglandin derivatives having improved pharmacological activity and enhanced tolerability. They can be employed for the treatment of glaucoma and ocular hypertension.

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