1088993-98-9

Basic information

• Product Name: [(3R,6R)-6-Methylpiperidin-3-yl]Methanol hcl
• Synonyms: [(3R,6R)-6-Methylpiperidin-3-yl]Methanol hcl;VTNSDDLUAVIRTL-ZJLYAJKPSA-N
• CAS NO: 1088993-98-9
• Molecular Formula: C₇H₁₅NO
• Molecular Weight: 165.66104
• EINECS: -0
• Mol File: 1088993-98-9.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: [(3R,6R)-6-Methylpiperidin-3-yl]Methanol hcl(CAS DataBase Reference)
• NIST Chemistry Reference: [(3R,6R)-6-Methylpiperidin-3-yl]Methanol hcl(1088993-98-9)
• EPA Substance Registry System: [(3R,6R)-6-Methylpiperidin-3-yl]Methanol hcl(1088993-98-9)

Safety Data

• Hazardous Substances Data: 1088993-98-9(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Synthesis:
[(3R,6R)-6-Methylpiperidin-3-yl]Methanol HCl is used as an intermediate in the pharmaceutical industry for the synthesis of various drugs. Its unique structure and reactivity make it a valuable component in the development of new medications.
Used in Organic Chemistry:
In the field of organic chemistry, [(3R,6R)-6-Methylpiperidin-3-yl]Methanol HCl is used as a reagent in numerous chemical reactions. Its ability to participate in a wide range of reactions contributes to the advancement of organic chemistry and the creation of novel compounds.
Used in Medicinal Chemistry:
[(3R,6R)-6-Methylpiperidin-3-yl]Methanol HCl is employed as a building block in medicinal chemistry for the synthesis of therapeutic drugs. Its structural properties and reactivity make it a promising candidate for the development of new pharmaceuticals with potential applications in treating various medical conditions.

Upstream product

• 1088993-89-8 (2R,5R)-benzyl 5-(hydroxymethyl)-2-methyl-piperidine-1-carboxylate 
• 1088994-05-1 (6R)-3-hydroxymethyl-6-methylpiperidin-2-one 
• 278789-37-0 (6-methyl-piperidin-3-yl)methanol 
• 59104-44-8 2-(3-oxo-butyl)malonic acid dimethyl ester 
• 1088994-03-9 (6R)-methyl-6-methyl-2-oxopiperidine-3-carboxylate 

Downstream Products

• 1222456-90-7 {(3R,6R)-6-methyl-1-[5-methyl-2-(2H-1,2,3-triazol-2-yl)benzoyl]piperidin-3-yl}methanol 
• 1088994-00-6 (2-(2H-1.2.3-triazol-2-yl)phenyl )((2R,5R)-5-(hydroxymethyl)-2-methylpiperidin-1-yl)methanone 
• 1088991-72-3 2-methyl-6-(((3R,6R)-6-methyl-1-(2-(2H-1,2,3-triazol-2-yl)benzoyl)piperidin-3-yl)methoxy)pyridine 

Relevant articles and documents

Convergent kilogram-scale synthesis of dual orexin receptor antagonist

MK-6096 is an orexin receptor antagonist in clinical trials for the treatment of insomnia. Herein we describe its first kilogram-scale synthesis. Chirality on the α-methylpiperidine core was introduced in a biocatalytic transamination using a three-enzyme system with excellent enantioselectivity (>99% ee). Low diastereoselectivity of the lactam reduction was overcome by development of a camphor sulfonic acid salt formation and dr upgrade. A chemoselective O-alkylation with 5-fluoro-2-hydroxypyridine was optimized and developed. Overall, 1.2 kg of MK-6069 was prepared in nine steps and 13% overall yield.

2,5-DISUBSTITUTED PIPERIDINE OREXIN RECEPTOR ANTAGONISTS

The present invention is directed to 2,5-disubstituted piperidine amide compounds which are antagonists of orexin receptors, and which are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which orexin receptors are involved.

PROCESS FOR THE PREPARATION OF AN OREXIN RECEPTOR ANTAGONIST

The present invention is directed to processes for preparing a pyridyl piperidine compound which is an antagonist of orexin receptors, and which is useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved.

PYRIDYL PIPERIDINE OREXIN RECEPTOR ANTAGONISTS

The present invention is. directed to pyridyl piperidine compounds of formula (I) which are antagonists of orexin receptors, and which are useful' in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which orexin receptors are involved.