cas 109-07-9, 2-Methylpiperazine | Articles data

Articles about 109-07-9Total 12 be found

Biocatalytic Access to Piperazines from Diamines and Dicarbonyls
Given the widespread importance of piperazines as building blocks for the production of pharmaceuticals, an efficient and selective synthesis is highly desirable. Here we show the direct synthesis of piperazines from 1,2-dicarbonyl and 1,2-diamine substrates using the R-selective imine reductase from Myxococcus stipitatus as biocatalyst. Various N- and C-substituted piperazines with high activity and excellent enantioselectivity were obtained under mild reaction conditions reaching up to 8.1 g per liter.
Borlinghaus, Niels,Gergel, Sebastian,Nestl, Bettina M.
p. 3727 - 3732
(2018/04/14)

Ruthenium-Catalyzed Amination of Secondary Alcohols Using Borrowing Hydrogen Methodology
A new ruthenium complex catalyzes the amination of primary and secondary alcohols and the regioselective mono- and sequential diamination of diols via the borrowing hydrogen pathway. Several variations on new intra- and intermolecular cyclizations of aminoalcohols, diols, and diamines lead to heterocyclic ring systems.
Marichev, Kostiantyn O.,Takacs, James M.
p. 2205 - 2210
(2016/04/26)

Production of phenylpiperazines
PROBLEM TO BE SOLVED: To provide a method for selectively producing piperazines with high yield.SOLUTION: Vicinal diamines and vicinal diols are subject to dehydrative cylization reaction in the presence of a Raney metal catalyst and a dehydration agent.
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Paragraph 0065

(2017/06/24)

METHOD FOR PRODUCING AMINES FROM SUGAR ALCOHOLS
The present invention relates to a process for preparing amines by reacting sugar alcohols with hydrogen and an aminating agent selected from the group of ammonia and primary and secondary amines in the presence of a catalyst at a temperature of from 100° C. to 400° C. and a pressure of from 1 to 40 MPa (from 10 to 400 bar). The catalyst preferably comprises one metal or a plurality of metals or one or more oxygen compounds of the metals of groups 8 and/or 9 and/or 10 and/or 11 of the Periodic Table of the Elements. The sugar alcohol is preferably obtained by hydrogenating the corresponding sugars. The invention further relates to the use of the reaction products as an additive in cement or concrete production and in other fields of use.
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Page/Page column 10

(2010/12/29)

METHOD FOR PRODUCING AMINES FROM GLYCERIN
The present invention relates to a process for preparing amines by reacting glycerol with hydrogen and an aminating agent from the group of ammonia and primary and secondary amines in the presence of a catalyst at a temperature of from 100° C. to 400° C. and a pressure of from 0.01 to 40 MPa (from 0.1 to 400 bar). Preference is given to using glycerol based on renewable raw materials. The catalyst preferably comprises one metal or a plurality of metals or one or more oxygen compounds of the metals of groups 8 and/or 9 and/or 10 and/or 11 of the Periodic Table of the Elements. The invention further relates to the use of the reaction products as an additive in cement or concrete production and in other fields of use. This invention further provides the compounds 1,2,3-triaminopropane, 2-aminomethyl-6-methylpiperazine, 2,5-bis(aminomethyl)piperazine and 2,6-bis(aminomethyl)piperazine.
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Page/Page column 12-13; 14

(2010/10/03)

PROCESS FOR PRODUCING NITROGENOUS HETEROCYCLIC COMPOUND
A nitrogenous heterocyclic compound such as 3-aminopyrrolidine derivative is produced by hydrogenolysis of an N-substituted nitrogenous heterocyclic compound with normal pressure hydrogen in a water-based solvent in presence of a catalyst. In the case an optically active 1-substituted-3-aminopyrrrolidine derivative is used as a raw material, an optically active 3-aminopyrrolidine derivative can be obtained as a product practically without racemination.
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Page/Page column 11-12

(2010/11/08)

Antiatherosclerotic and antithrombotic 1-benzopyran-4-ones and 2-amino-1,3-benzoxazine-4-ones
This invention relates to compounds of Formula I STR1 which are useful in association with a pharmaceutical carrier as antiatherosclerotic agents. In addition, various compounds of Formula I are useful inhibitors of cell proliferation.
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(2008/06/13)

8-chloro-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid and alkyl esters thereof
The invention is related to 7-amino-1-cyclopropyl-6,8-dihalogeno-1,4-dihydro-4-oxo-3-quinoline-carboxylic acids of the formula (I) STR1 in which X1, X2, R1 and R2 have the meaning as pointed out in the following specification. Moreover, the invention is related to a process for the production of the compounds of formula (I) and to antibacterial agents containing them.
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(2008/06/13)

Antiatherosclerotic and antithrombotic 2-amino-6-phenyl-4H-pyran-4-ones
This invention relates to compounds of Formula I STR1 which are useful as antiatherosclerotic agents and inhibitors of cell proliferation for the treatment of proliferative diseases. In addition, various compounds of Formula I are useful inhibitors of platelet aggregation.
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(2008/06/13)

2,3,4,5-tetrahalogenobenzene derivatives
2,3,4,5-trihalogenobenzene derivatives of the formula STR1 in which R is --COOH, --COCl, --COF, --CN, --CONH2, --CH2 OH, --CH2 Cl, --CHCl2, --CCl3 or --CHO, R1 is H, Cl or F, and R2 is Cl or F, it only being possible for R1 or R2 to be F, and processes for their preparation starting from benzonitriles reacted with potassium fluoride. The novel compounds are intermediates for antibacterials such as quinolone carboxylic acids.
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(2008/06/13)

2-SUBSTITUTED N,N'-DITRIMETHOXYBENZOYL PIPERAZINES AND THERAPEUTIC COMPOSITIONS CONTAINING THEM
This invention relates to piperazine derivatives of the general formula I STR1 wherein--(CH 2) n--represents a straight or branched chain alkyl group having from n=1 to n=20 carbon atoms, and R represents a hydrogen atom, a branched alkyl group, a cycloalkyl group having from 5 to 10 carbon atoms, a phenyl group, optionally substituted by one or several chlorine atoms, methyl or methoxy groups, or straight or branched chain alkenyl groups having from 3 to 11 carbon atoms, to a preparation process of said compounds and to therapeutic compositions containing them as an active ingredient.
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(2008/06/13)

Reduction of Heterocycles with Nickel-Aluminum Alloy
Pyrazines, pyridazines, isoxazoles, oxazole, 4-methylpyrimidine, and indole are reduced by nickel-aluminum alloy in potassium hydroxide solution.The reaction is simple to carry out and does not require special apparatus or hydrogen atmospheres.The products were the fully hydrogenated species although benzene rings were not attacked. 4-Methylpyrimidine gave 1,3-diaminobutane and oxazole gave 2-(methylamino)ethanol.It was found that the reaction frequently exhibited an induction period.
Lunn, George
p. 1043 - 1046
(2007/10/02)