Synthesis of Some New Pyrimidopyrimidines. Isolation of Stable Covalent Hydrated Pyrimidopyrimidines.
4-amino-5-phenylpyrimidine 2 reacts with alkyl malonic acids 3 in acetic anhydride under reflux to give 2(4)H-pyrimidopyrimidines 4.From these reactions some covalent hydrated pyrimidopyrimidines 5 were also isolated, where the addition of the water molecule occured to the 6,7 C=N bond.This covalent hydration is irreversible.
Pegiadou-Koemtjopoulou, S.
p. 1063 - 1065
(2007/10/02)
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