Iron-Catalyzed Highly Enantioselective Hydrogenation of Alkenes
Here, we reported for the first time an iron-catalyzed highly enantioselective hydrogenation of minimally functionalized 1,1-disubstituted alkenes to access chiral alkanes with full conversion and excellent ee. A novel chiral 8-oxazoline iminoquinoline ligand and its iron complex have been designed and synthesized. This protocol is operationally simple by using 1 atm of hydrogen gas and shows good functional group tolerance. A primary mechanism has been proposed by the deuterium-labeling experiments.
Highly stereoselective hydrocarbation of terminal alkynes via Pt-Catalyzed Hydrosilylation/Pd-Catalyzed cross-coupling reactions
(matrix presented) The formal addition of an aryl-H or alkenyl-H bond across a terminal alkyne has been accomplished by the combination of platinum-catalyzed hydrosilylation followed by palladium-catalyzed cross-coupling. The use of the t-Bu3P-Pt(DVDS) catalyst in combination with tetramethyldisiloxane gave excellent regio- and stereoselectivity with a number of alkyne substrates. Subsequent, fluoride-promoted cross-coupling proceeded in high yield and stereospecificity for a variety of aryl halides.
Denmark, Scott E.,Wang, Zhigang
p. 1073 - 1076
(2007/10/03)
THE REACTION OF QUATERNARY AMMONIUM SALTS DERIVED FROM 2-ARYL-3-(N,N-DIMETHYLAMINO)-1-PROPENES WITH OXYGEN CONTAINING NUCLEOPHILES
A variety of quaternary ammonium salts derived from 2-aryl-3-(N,N-dimethylamino)-1-propenes have been converted to the corresponding alkyl and fluoroalkyl ethers by displacement of the ammonium group.This procedure represents an efficient means for the construction of 2-aryl substituted allylic ethers.
Gupton, John T.,DiCesare, John,Brown, Joan,Idoux, John P.
p. 1413 - 1422
(2007/10/02)
Reaction of 2-Aryl-3-(N,N-dimethylamino)-1-propenes and Their Corresponding Quaternary Ammonium Salts with Organometallic Species and Reducing Agents
A series of 2-aryl-3-(N,N-dimethylamino)-1-propenes and their corresponding quaternary ammonium salts were reacted with a variety of organometallic species and reducing agents.The utility of such reactions for the preparation of α-substituted styrene derivatives is discussed.
Gupton, John T.,Layman, William J.
p. 3683 - 3686
(2007/10/02)
THE REACTION OF 2-ARYL-N,N-DIMETHYLALLYLIC AMINES WITH ORGANOLITHIUM REAGENTS
A variety of 2-aryl-N,N-dimethylallylic amines have been reacted with butyllithium and t-butyllithium to produce the corresponding 3-butyl and 3-t-butyl substituted 2-aryl-propenes.This procedure represents a convenient and clean method for the synthesis
Gupton, John T.,Layman, William J.,Forman, James T.
p. 1393 - 1400
(2007/10/02)
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