109142-49-6

Basic information

• Product Name: N-Hydroxy Norfloxacin
• Synonyms: N-Hydroxy Norfloxacin;1-Ethyl-6-fluoro-1,4-dihydro-7-(4-hydroxy-1-piperazinyl)-4-oxo-
• CAS NO: 109142-49-6
• Molecular Formula: C16H18FN3O4
• Molecular Weight: 335.3302232
• Product Categories: Intermediates & Fine Chemicals;Pharmaceuticals;Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 109142-49-6.mol

Chemical Properties

• Appearance: /
• Storage Temp.: -20°C Freezer
• Solubility: DMSO (Slightly)
• CAS DataBase Reference: N-Hydroxy Norfloxacin(CAS DataBase Reference)
• NIST Chemistry Reference: N-Hydroxy Norfloxacin(109142-49-6)
• EPA Substance Registry System: N-Hydroxy Norfloxacin(109142-49-6)

Safety Data

• Hazardous Substances Data: 109142-49-6(Hazardous Substances Data)

Usage

Chemical Properties

Light Beige Solid

Uses

A metabolite of Norfloxacin (N681000).

Upstream product

• 103240-27-3 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7<4-(3-oxobutyl)-1-piperazinyl>quinoline-3-carboxylic acid 
• 70458-96-7 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid 

Relevant articles and documents

Synthesis of Antimicrobial Agents. 3. Syntheses and Antibacterial Activities of 7-(4-Hydroxypiperazin-1-yl)quinolones

A series of novel pyridone carboxylic acids having a 4-hydroxypiperazinyl group at the 7-position of norfloxacin and ciprofloxacin were prepared.The in vivo antibacterial efficacies of these compounds were superior to those of corresponding piperazinyl derivatives.From the results of the studies on the pharmacokinetic profile and toxicity, the 4-hydroxypiperazinyl derivatives were confirmed to be pharmacologically superior to corresponding piperazinyl derivatives.Thus, a 4-hydroxypiperazinyl group was revealed to be a beneficial substituent for potential use in future quinolone antibacterials.

Quinolinecarboxylic acid compounds and antimicrobial agent containing the same

Novel compounds of the formula: STR1 wherein R is ethyl, 2-fluoroethyl or cyclopropyl, and X is hydrogen atom or fluorine atom, and a pharmaceutically acceptable salt thereof, which have excellent antimicrobial activities in vivo and hence are useful as an antimicrobial agent, and an antimicrobial composition containing said compound as an active ingredient, and processes for the preparation of the compounds.