A new strategy for the synthesis of optically pure β-fluoroalkyl β-amino acid derivatives
(Chemical Equation Presented) The first general approach for the diastereoselective formation of a variety of optically pure anti/β- fluoroalkyl β-amino acid derivatives is described. The process relies on the stereocontrolled reaction, mediated by a remo
Fustero, Santos,Pozo, Carlos Del,Catalan, Silvia,Aleman, Jose,Parra, Alejandro,Marcos, Vanesa,Ruano, Jose Luis Garcia
supporting information; experimental part
p. 641 - 644
(2009/08/14)
Anionic-anionic asymmetric tandem reactions: One-pot synthesis of optically pure fluorinated indolines from 2-p-tolylsulfinyl alkylbenzenes
Chirality switch up: A novel strategy has been developed to give optically pure fluorinated indolines with one or two stereogenic centers (see scheme; AN = nucleophilic addition, PG = protecting group, SNAr = intramolecular nucleophilic aromatic substitution, Tol = tolyl). Almost complete stereoselectivity and mild reaction conditions are the key features of the title reaction. (Chemical Equation Presented)