- Copper(I) Iodide-Catalyzed Sulfenylation of Maleimides and Related 3-Indolylmaleimides with Thiols
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An efficient copper(I) iodide-catalyzed sulfenylation of maleimides and related 3-indolylmaleimides with thiols has been developed in the presence of fluoroboric acid. Several 3-thiomaleimides and 3-indolyl-4-thiomaleimides were obtained with good yields under ligand-free conditions. The methods are simple, practical and show good functional group tolerance. (Figure presented.).
- Yang, Zhen-Hua,An, Yu-Long,Chen, Ying,Shao, Zhi-Yu,Zhao, Sheng-Yin
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- Iodine-Promoted C(sp 2)-H thiolation of maleimides with dimethyl sulfoxide and thiols
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Iodine-promoted C(sp 2)-H methylthiolation of maleimides using DMSO as synthon has been developed to afford 3-methylthiomaleimides in moderate yields under metal-free conditions. In addition, 3-thiomaleimides were synthesized from maleimides an
- Tan, Hong-Ru,Wang, Lun,Yang, Zhen-Hua,Zhao, Sheng-Yin,Zhu, Jia-Nan
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- Copper-catalyzed intermolecular thioamination of maleimides with thiols and formamides: A one-step construction of 3-Amino-4-Thiomaleimides using formamides as nitrogen sources
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A highly efficient copper-catalyzed intermolecular C(sp2)-H thioamination of maleimides with thiols and formamides in the presence of fluoroboric acid is reported using various readily available formamides as nitrogen sources and solvents. A diverse range of 3-Amino-4-Thiomaleimides is obtained with good yields under mild conditions, involving C-N and C-S bond formation. This methodology enriches current C-N and C-S bond formation chemistry and features operational simplicity and excellent functional-group tolerance.
- Yang, Zhen-Hua,Zhu, Jia-Nan,Jin, Ze-Hui,Zheng, Jian,Zhao, Sheng-Yin
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p. 4627 - 4636
(2019/02/01)
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- Three-Component Coupling Reactions of Maleimides, Thiols, and Amines: One-Step Construction of 3,4-Heteroatom-functionalized Maleimides by Copper-Catalyzed C(sp2)?H Thioamination
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A copper-catalyzed intermolecular thioamination of maleimides with thiols and amines has been developed. A diverse range of 3-amino-4-thiomaleimides and 3,4-dihydropyrrolo[3,4-b][1,4]thiazine-5,7(2H,6H)-diones were obtained with good yields, involving C?N and C?S bond formations. This methodology is very practical and features high atom economy, excellent functional group tolerance. (Figure presented.).
- Yang, Zhen-Hua,Tan, Hong-Ru,An, Yu-Long,Zhao, Yu-Wei,Lin, Hao-Peng,Zhao, Sheng-Yin
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supporting information
p. 173 - 179
(2017/11/22)
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