Antiproliferative and protein kinase binding activities of some N 6, 5'-bis-ureido 5'-amino-5'-deoxyadenosine derivatives
Two novel N6,5'-bis-ureido 5'-amino-5'-deoxyadenosine derivatives are shown to inhibit tumor cell growth in the NCI 60 human tumor cell panel. Compounds 2c and 2d exhibited GI50 values of 1-6 M in 35 and 14 cell lines, respectively. Compound 2c was shown
Peterson, Matt A.,Oliveira, Marcelio,Christiansen, Michael A.