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CAS

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1094322-91-4

1-[2-(4-Morpholinyl)ethoxy] is an organic compound that plays a crucial role in the synthesis of Mycophenolate Mofetil, a medication used to prevent organ transplant rejection. It is characterized by the presence of a morpholine group attached to an ethoxy chain, which is esterified with mycophenolic acid to produce the final drug.

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  • 1094322-91-4 Structure

  • Basic information

    1. Product Name: 1-[2-(4-Morpholinyl)ethoxy]
    2. Synonyms: 1-[2-(4-Morpholinyl)ethoxy];1-[2-(4-Morpholinyl)ethoxy] Mycophenolate Mofetil;Mycophenolate Mofetil EP IMpurity B;(R,E)-2-morpholinoethyl 6-(4-hydroxy-6-methoxy-7-methyl-1-(2-morpholinoethoxy)-3-oxo-1,3-dihydroisobenzofuran-5-yl)-4-methylhex-4-enoate
    3. CAS NO:1094322-91-4
    4. Molecular Formula: C29H42N2O9
    5. Molecular Weight: 562.65178
    6. EINECS: N/A
    7. Product Categories: Heterocycles;Impurities;Intermediates & Fine Chemicals;Pharmaceuticals
    8. Mol File: 1094322-91-4.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 730.9±60.0 °C(Predicted)
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.28±0.1 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. PKA: 9.62±0.40(Predicted)
    10. CAS DataBase Reference: 1-[2-(4-Morpholinyl)ethoxy](CAS DataBase Reference)
    11. NIST Chemistry Reference: 1-[2-(4-Morpholinyl)ethoxy](1094322-91-4)
    12. EPA Substance Registry System: 1-[2-(4-Morpholinyl)ethoxy](1094322-91-4)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1094322-91-4(Hazardous Substances Data)

1094322-91-4 Usage

Uses

Used in Pharmaceutical Industry:
1-[2-(4-Morpholinyl)ethoxy] is used as an intermediate in the synthesis of Mycophenolate Mofetil for its role in preventing organ transplant rejection. It is esterified with mycophenolic acid to form the active pharmaceutical ingredient, which helps suppress the immune system and reduce the risk of transplant rejection.
Additionally, it is important to note that Mycophenolate Mofetil (M831450) impurity is present in the process for the purification of Mycophenolate mofetil upon esterification of mycophenolic acid with 2-morpholinoethanol. This impurity must be carefully managed and controlled during the manufacturing process to ensure the safety and efficacy of the final drug product.

Check Digit Verification of cas no

The CAS Registry Mumber 1094322-91-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,9,4,3,2 and 2 respectively; the second part has 2 digits, 9 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 1094322-91:
(9*1)+(8*0)+(7*9)+(6*4)+(5*3)+(4*2)+(3*2)+(2*9)+(1*1)=144
144 % 10 = 4
So 1094322-91-4 is a valid CAS Registry Number.

1094322-91-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 14, 2017

Revision Date: Aug 14, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-[2-(4-Morpholinyl)ethoxy]

1.2 Other means of identification

Product number -
Other names 2-morpholin-4-ylethyl (E)-6-[4-hydroxy-6-methoxy-7-methyl-1-(2-morpholin-4-ylethoxy)-3-oxo-1H-2-benzofuran-5-yl]-4-methylhex-4-enoate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1094322-91-4 SDS

1094322-91-4Downstream Products

1094322-91-4Relevant articles and documents

METHOD FOR THE PURIFICATION OF MYCOPHENOLATE MOFETIL

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Page/Page column 7, (2009/03/07)

The present invention provides a method for the preparation of mycophenolate mofetil wherein mycophenolic acid or an amine salt of mycophenolic acid is esterified with 2-morpholinoethanol, the resulting mixture is extracted into water at a pH-value between 1.0 and 3.0, and mycophenolate mofetil is back-extracted in a water-immiscible solvent at a pH-value between 3.0 and 5.0.

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